Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PRIMPOL"”.
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Genetic interactions of repriming and translesion synthesis
PRIMPOL is the only known eukaryotic primase outside of the core replisome. It has been previously shown to restart DNA synthesis past replication impediments such as DNA damage or non-B-DNA secondary structures. To probe the genetic interactions of PRIMPOL, genome-wide CRISPR/Cas9 knockout screens …
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UNRAVELING THE MOLECULAR MECHANISM OF BRCA2-POLTETA INTERPLAY IN PREVENTING SSDNA GAP ACCUMULATION DURING DNA REPLICATION
… through repriming ahead of the lesion by PRIMPOL. Notably, we found that POLθ fills these ssDNA gaps, and its absence, along with BRCA2, results in massive DNA damage and cell death. Moreover, APEX1-deficient cells, exhibiting increased endogenous AP sites, display ssDNA gaps and …
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Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… nucleotide excision repair and POLK and PRIMPOL that function in the translesion synthesis pathway. Moreover, knockout mutations of mTORC1 regulatory proteins such as tuberous sclerosis complex (TSC1 and TSC2) and STK11 were identified as potential markers to duocarmycin analogues …
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Control of Replication Fork Stability by Chromatin and S-phase Checkpoint
… que la expresión heteróloga de la enzima humana PrimPol es capaz de rescatar los fenotipos de sensibilidad a estrés replicativo y degradación que se observan en ausencia del checkpoint de fase S.