Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PREX1"”.
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
PREX protein family (PREX1 and PREX2) guanine-nucleotide exchange factors (GEFs) activate the small G protein Rac. They are important in many physiological and pathophysiological processes, including inflammation, neuronal plasticity, cancer progression and metastasis, with an exciting new role in …
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IDENTIFYING GENES THAT CONTRIBUTE TO TYPE 2 DIABETES SUSCEPTIBILITY IN CAUCASIAN AND AFRICAN AMERICANS
… T2DM for SNPs within the genes NCOA5, CDH22, and PREX1. We aimed to evaluate these three genes in two independent Caucasian case-control populations. Seventy two SNPs were genotyped in 300 diabetic nephropathy patients and 310 controls. Evidence of association with T2DM was observed in all three …
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The P-Rex1 Regulator Norbin Suppressess Neutrophil-Dependent Antibacterial Immunity
… Norbin in myeloid cells and with combined Norbin/Prex1 deficiency. Unexpectedly, I found increased adhesion, spreading, ROS production and degranulation responses in isolated Norbin-deficient neutrophils. Moreover, Norbin-deficient neutrophils had an increased ROS-dependent capacity to kill …
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Identification of the Role of P-Rex1 and its Adaptor Functions in Neutrophils
… function, we employed both P-Rex1 knockout (Prex1–/–) and catalytically inactive (Prex1GD) mouse models to examine neutrophil responses, including migration, ROS production, degranulation, phagocytosis, neutrophil extracellular trap formation, and bacterial clearance. Our results show that …