Global ETD Search
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Showing 1 to 2 of 2 for “"PRDM14"”.
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Signalling and transcriptional regulation of human primordial germ cell specification
… On the other hand, a key pluripotency factor PRDM14 is crucial for mouse PGC specification, but its role in human PGC development is unclear. I designed genetic approaches to address PRDM14 involvement in human pluripotency versus PGC specification. To achieve inducible loss of function, I …
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Defining the essential regulators of naive human pluripotent stem cell reprogramming
… naïve-specific interaction between PRC1.3 and PRDM14, which cooperate in transcriptional repression of PRC1.3 target genes, I also discovered a developmentally-regulated composition shift in the PRC1.3 complex between human naïve and primed PSCs, which was corroborated in early human embryo …