Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"PRDM1"”.
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LDB-1 AND SWI/SNF CHROMATIN REMODELING COMPLEX PARTICIPATE IN THE TRANSCRIPTIONAL ACTIVATION BY C. ELEGANS BLIMP1/PRDM1
… transcriptional repressor BLIMP1/PRDM1. BLIMP1/PRDM1 and its orthologs are well studied as transcriptional repressors in many species including humans and mice. Interestingly, we found that in C. elegans, BLMP-1 acts as a direct transcriptional activator of bed-3, a gene required …
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blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
… mutants, I was able to confirm that loss of PRDM1/Blimp1 homolog blmp-1 served as a strong enhancer of the let-60(n1046) Muv phenotype. In addition, blmp-1(tm548) mutant worms are not Muv. I chose to investigate one of these genes, called blmp-1, in great detail because of known roles of its …
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Characterisation of genetic complexity in chronic lymphocytic leukaemia
… regions (MOR) on del(6q) to the ATG5 and PRDM1 genes. Further autophagy related genes were also found to be present in other MORs. Analysis of the autophagy pathway at the protein level showed higher autophagy activity in primary CLL cells compared with age-matched controls. NGS-IgHV …
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Molecular analysis of germ cell specification
… signals: cells expressing early PGC markers (i.e Prdm1, Ap2y, Esrrb) and cells expressing mesoderm markers (i.e T, Mixl1, Wnt3a). These populations are mutually exclusive, as germline markers are expressed in different cells than mesoderm markers. Moreover, commitment of cells to these fates is …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… This was confirmed by upregulation of BCL2 and PRDM1 and downregulation of BCL6. Surface Ig expression revealed that CD10+CD27+ B cells are a subset memory B cells that have undergone Ig class switching. Thus we conclude that CD10+CD27+ B cells represent a subset of IgM- memory B cells.
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Isolation, characterisation and in vitro potential of Oogonial stem cells
… NANOG, POU5F1 (OCT4), IFITM3 (fragilis), STELLA, PRDM1 (BLIMP1), and C-KIT, indicating their early germline nature. Investigation of neo-oogenesis potential revealed that putative human OSCs were associated rarely with fetal somatic cells in primordial follicle-like structures, but could not be …
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Genesis of the human germline
… a core germline program, including induction of PRDM1 by SOX17 and maintenance of pluripotency factors, POU5F1 and NANOG. I also explored PGC competence and specification using highly resolved single-cell transcriptomic profiling of our in vitro PGC-like cells (PGCLC). Using an integrative …
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A Leap of Fate: Fluid identity, functional modules, and flexible strategies for transcription factor-based reprogramming
… an improvement on the existing method of XBP1 or PRDM1/BLIMP1 over-expression. Chapter 5 attempts to address how predictive framework might be adapted for the design of a truly synthetic cell type: a functionally defined target cell. It proposes the concept of a reprogramming dictionary, …
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Topographie molekularer Faktoren der Keimzellentwicklung während der frühembryonalen Entwicklung des Kaninchens
Keimzellen sind das Instrument der sexuellen Fortpflanzung und damit eine wesentliche Grundlage für die Vielfalt der Lebensformen auf der Erde. Die Repression des somatischen Entwicklungsprogrammes durch Präformation oder Epigenese ist der Schlüsselmechanismus ihrer Entstehung in der embryonalen …