Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"PR1"”.
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Development and Characterization of A Bi-Specific Antibody Targeting Hla-A2/Pr1
… leukemia antigen, HLA-A2 restricted peptide PR1.Previously, we have conducted pre-clinical development and humanization of a T cell receptor-like monoclonal antibody (h8F4) that targets PR1/HLA-A2 and eliminates AML xenografts by antibody-dependent cellular cytotoxicity (ADCC) following …
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… effective antigen-targeting immunotherapies. PR1 is a nonameric human leukocyte antigen (HLA)-A2 restricted leukemia-associated antigen derived from serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE and P3 are primarily expressed in cells of myeloid lineage including …
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Cross-Presentation Is A Source of Tumor Antigens For Multiple Myeloma Immunotherapy
… capacity of multiple myeloma to cross-present PR1, a human leukocyte antigen (HLA)-A2 nonameric peptide that is derived from neutrophil elastase (NE) and proteinase 3 (P3), and the ability to treat multiple myeloma using PR1-targeting immunotherapies. Here we demonstrate that multiple myeloma …
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The Molecular Consequences of CK2-mediated Phosphorylation of the TGA2 Transcription Factor within Systemic Acquired Resistance of Arabidopsis thaliana
… plant defence is called pathogenesis-related 1 (PR1) and is under the control of several protein regulators. TGA II-clade transcription factors (namely TGA2) repress PR1 activity prior to infection by forming large oligomeric complexes effectively blocking gene transcription. After pathogen …
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Modulating Avidity of H8F4-Car By Regulation of Expression Via Codon Modification
… of targeting the leukemia-associated antigen PR1 in the setting of AML. PR1 is an HLA-A2-restricted nonameric peptide derived from serine proteases neutrophil elastase and proteinase 3, is overexpressed on myeloid leukemia cells, and expressed at normal low levels in healthy hematopoietic …
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A Novel, Codon-Based Approach to Preserve On-Tumor Activity and Reduce Off-Tumor Toxicity of Chimeric Antigen Receptor (CAR) T Cells
… which targets the leukemia-associated antigen, PR1. PR1 is presented in the context of HLA-A2, is overexpressed on AML myeloblasts, and expressed at low levels in healthy hematopoietic cells. As with most CAR-T cells, the targeting of Hu8F4-CAR against PR1/HLA-A2 renders susceptibility to …
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Evolução molecular Darwiniana nas proteínas relacionadas à patogênese (PRs) em plantas
… 15 tipos de proteínas relacionadas à patogênese (PR1-PR15), quanto a 14 modelos diferentes de seleção. Tanto quanto se possa avaliar, não há qualquer estudo disponível na literatura que tenha examinado de maneira homogênea tal número de seqüências de forma tão abrangente.
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Molecular biology of the entomopathogenic fungus Beauveria bassiana : insect-cuticle degrading enzymes and development of a new selection marker for fungal transformation
… the role of cuticle-degrading proteases (PR1 and PR2) as well as phospholipase B (PLB) in fungal pathogens and their correlations to virulence observed in either M. anisopliae or C. albicans, these genes were cloned from B. bassiana 252. Two PLB-encoding genes (plb1 and plb2, 57% identity) …
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Untersuchungen zum anatomischen, physiologischen und molekularbiologischen Abwehrverhalten an gesunden und geschädigten Buchen (Fagus sylvatica L.) mit der Symptomatik „Buchenkomplexkrankheit”
… Rindenmaterial eine erhöhte Induktion des PR1 Gens und des ACS2 Gens zeigte. Eine verstärkte PR1 Induktion ist ein Beweis für erhöhte Abwehrreaktionen in der Pflanze, während ACS2 an der Ethylenbildung beteiligt ist.Mittels Microarray Analysen an Buchenrinde wurde gezeigt, dass von …
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Cellular Uptake of Neutrohpil Elastase Links Inflammation to Adaptive Immunity
… cross-present the NE- and PR3-derived peptide PR1 rendering them susceptible to PR1-targeted therapies. Taken together, our data support a role for NE uptake in modulating adaptive immune responses against breast cancer.</p>
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Reproductive and somatic functions of RAD51A and BRCA2 genes in maize
… this experiment showed that the defense genes PR1(PATHOGENESIS-RELATED PROTEIN 1, or Zm00001d018738) and PRP3 (PATHOGENESIS-RELATED PROTEIN 3, or Zm00001d048947) had increased transcription in inoculated samples. There was also increased transcription of the Bowman-Birk type trypsin inhibitor …
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Neutron Scattering Studies of Unusual Spin Structure and Local Correlation in Complex Oxides
… correlations in single crystals of Pr1−xCaxMnO3 for various hole-doping concentrations has 1) provided direct evidence of magnetic phase separation and 2) revealed a critical doping concentration close to (x = 0.35) that divides the inhomogeneous from homogenous CO state. Preliminary …
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The role of SENSITIVE TO FREEZING6 in plant tolerance to stress
… META CASPASE8 (MC8), PATHOGENESIS RELATED1 (PR1) and ENHANCED DISEASE SUSCEPTIBILITY5 (EDS5).
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Indução de resistência em tomateiro à Meloidogyne javanica por Pochonia chlamydosporia e Trichoderma atroviride
… atividade da rota de defesa do ácido salicílico (PR1), a qual bloqueou a sinalização via ácido jasmônico (LOX1). Ademais, os genes da peroxidase (TPX1), da NADPH oxidase (LERBOH1) e da chalcona sintase (LECHS2) apresentaram expressão diferencial ao longo do tempo, demonstrando a sua participação e …
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Cord Blood-Derived Invariant Natural Killer T Cells as a Platform for Allogeneic Chimeric Antigen Receptor Cell Therapy
… acute myeloid leukemia (AML) associated antigen PR1 presented in the context of HLA/A2*01. We show CB-8F4CAR-iNKT cells expand in greater numbers compared to AB-8F4CAR-iNKT cells with equivalent 8F4CAR expression and iNKT cell purity. CB-8F4CAR-iNKT cells exhibit significantly higher CD62L …
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Physiological, biochemical and molecular aspects of induced resistance in maize against Bipolaris maydis infection using a zinc-polyphenolic compound and silicon
… treatment. Defense-related genes (IGL, CHS02, PR1, PAL3, LOX3, CHI, and GLU) were up-regulated for IR stimulus-sprayed plants compared to control plants infected by B. maydis. These findings highlight the potential of using this IR stimulus for MLB management. In the second study, we …
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Engineered microtissue platforms for modeling human pathophysiology and drug metabolism
… panel of soluble stimuli, TGF-p and the TGF-pR1/2 inhibitor LY2157299 were found to have opposing effects on the proliferation of lung adenocarcinoma cells in microtissues vs. in 2-dimensional culture, affirming a potential role for 3D models in the investigation of cancer therapies. Next, we …
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INNOVATIVE APPROACHES TO PLANT PROTECTION AND PRODUCE SAFETY THROUGH HIGH-PRECISION PLANT MANAGEMENT SYSTEMS
… analysis indicated early upregulation of PAL and PR1, pointing to activation of salicylic acid–dependent defense and phenylpropanoid pathways in response to both UV-C and fungal application. Moreover, hyperspectral imaging enabled partial discrimination between healthy and infected tissues, …