Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PR-AUC"”.
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High Precision Binary Trait Association on PhylogeneticTrees
… association analyses. Microbial GWAS approaches emerged to address this, but modern methods often lack the statistical power to detect associations while controlling false discoveries, and face computational limits at scale. Here, we present SimPhyNI (Simulation-based Phylogenetic …
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Post-Wildfire Debris Flow Susceptibility and Preconditioning Factors in the Central Okanagan
… in the temperate continental regions of the province are primarily limited to anthropogenic and specific large events. We document 197 debris flows in and around the Regional District of Central Okanagan and the physical properties governing their magnitudes and spatial distributions. These …
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Understanding and predicting pulmonary exacerbations in Cystic Fibrosis using Machine Learning
Cystic Fibrosis (CF) is the most prevalent, life-limiting, multi-system, genetic disorder, affecting over 100,000 individuals globally. The condition is caused by mutations in the cystic fibrosis trans-membrane conductance regulator (CFTR) gene, which corrupts the instructions for making the …
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Improved In Silico Methods for Target Deconvolution in Phenotypic Screens
Target-based screening projects for bioactive (orphan) compounds have been shown in many cases to be insufficiently predictive for in vivo efficacy, leading to attrition in clinical trials. Phenotypic screening has hence undergone a renaissance in both academia and in the pharmaceutical industry, …