Global ETD Search
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Showing 1 to 3 of 3 for “"PPP1R15A"”.
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The eIF2 phosphatase: characterization and modulation
… preferentially expressed during the ISR is PPP1R15A, a regulatory subunit of Protein Phosphatase 1 (PP1). The PP1/PPP1R15A holophosphatase dephosphorylates eIF2 and terminates the ISR once the stresses are resolved. Hence, eIF2 kinases and phosphatases work together to control levels of …
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Towards understanding substrate recruitment by PP1 holophosphatases
… expressed PPP1R15B (R15B) or stress inducible PPP1R15A (R15A). These holoenzymes catalyse the dephosphorylation of eIF2α at serine 51, an important signalling event in the integrated stress response pathway, enabling cells to deal with various stresses. The substrate recruitment mechanism of …
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The Effect of Mebendazole and RAN Mediated Pathways on Human Breast Cancer Cells
Breast cancer is a prevalent form of cancer that affects millions of people worldwide, accounting for 25% of all female cancers and the second leading cause of cancer-related deaths in women, following lung cancer. Breast cancer metastasis to other body parts is expected, with bones, liver, lungs, …