Global ETD Search
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Showing 1 to 4 of 4 for “"PPIases"”.
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Identification of Peptidyl-prolyl cis/trans isomerases affecting Drosophila circadian rhythms
… real-time RT–PCR 11 Ⅲ. RESULTS 12 A. PPIases alters Drosophila circadian activity rhythms 12 B. DOD 19 1. Daily cycle of core clock protein in dod knockdown flies 19 2. Degradatin of PER is attenuated when DOD is overexpressed in S2 cells 22 3. DOD interacts with hyperphosphorylated …
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Isomerization-Locked Alkene Analogues of Xaa–Pro Dipeptides in the Proteins Collagen and Bora
… the prolyl amide is catalyzed by enzymes called PPIases. The PPIase Pin1 specifically catalyzes isomerization of the pSer–Pro sequence from the cis-conformation to the trans-conformation. Pin1 plays a crucial role in the G2→M transition of the cell cycle, implying the importance of cis-trans …
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Pin1: WW domain ligands, catalytic inhibitors, and the mechanism
The peptidyl prolyl cis/trans isomerase, PPIase, has been the focus of numerous studies in the field of cell cycle regulation since proline-directed phosphorylation is an essential signaling mechanism that might arrest cancer proliferation. Pin1 is the first phosphorylation-dependent PPIase enzyme …
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Entwicklung eines GFP-Reportersystems in Legionella und molekularbiologische Funktionsanalyse des Legionella Mip-Proteins
Das fakultativ intrazelluläre Bakterium Legionella pneumophila wurde erstmals 1977 als Erreger der Legionellose, einer schweren atypisch verlaufenden Pneumonie identifiziert. Es besitzt ein duales Wirtssystem und kann sich sowohl in aquatischen Habitaten in Protozoen als auch in phagozytierenden …