Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"PPARgamma"”.
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PPARgamma-Polymorphismus (Pro12Ala)
… häufig auftretenden Pro 12 Ala Mutation in PPARgamma auf das Körpergewichtund den Gewichtsverlauf nach gastric banding Operationen untersucht haben. Weiter untersuchten wir Parameter des Glukosestoffwechsels (Glukose, Insulin, C-Peptid). PPARs sind transkriptionelle Regulatoren der …
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Regulation of PPARgamma Activity by mTOR in Adipogenesis
… feedback loop between C/EBPalpha and PPARgamma. The PPARgamma activity toward its target genes was specifically inhibited by rapamycin upon insulin stimulation. I demonstrate that PPARgamma activity is dependent on amino acid sufficiency, revealing a molecular link between nutrient …
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Les effets de traitements aux acides gras polyinsatures omega-3 a longue chaine sur la secretion d'adiponectine de preadipocytes humains differencies
… if this effect is under the influence of PPARgamma nuclear receptors. Human adipocytes were exposed to 125muM of DHA or EPA for 24 h. Levels of adiponectin following DHA treatment increased from 0.19+/-0.02 to 0.22+/-0.01 ng/mug, or 13.6% (P<0.05) and from 0.19+/-0.02 to 0.24+/-0.06 …
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Abscisic acid ameliorates glucose tolerance and obesity-induced inflammation
… proliferator-activated receptor gamma (PPARgamma ). Due to the many side-effects of TZDs, our laboratory sought out a natural phytochemical, abscisic acid (ABA), with chemical similarities to TZDs. Our first study demonstrated that ABA activates PPARgamma in vitro and significantly …
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Two molecular mechanisms of apoptosis resistance
… transcription. In cells transfected with PPARgamma, increased levels of bcl-2 mRNA and Bcl-2 protein were seen as compared to empty vector-transfected cells. When treated with bile acids to induce apoptosis, the PPARgamma-transfected cells were twice as resistant as empty …
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Genetic Analysis of Adipose Lineage and Development
… demonstrate the application of one of the tools, PPARgamma tTA, in exploring some important aspects of adipose development, such as the adipose depot specification, the identity of adipocyte progenitor cells and their anatomical niche. Adipose tissues form throughout the body in various places in …
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From Flies to Mice: Drosophila as a Model System to Study Fat Biology
… this function early in adipogenesis, upstream of PPARgamma, potentially acting as a molecular switch diverting preadipocytes and mesenchymal prescursors away from adipogenesis and towards osteogenesis. In another study, I investigated the role of Adipose, an evolutionarily conserved gene isolated …
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Grape Seed Extract as an Adjunct for Modulating Colon Carcinogenesis
… and iNOS and decreased expression of PPARgamma, and increased expression of COX-2 by immunohistochemistry. To carry out experimental analysis of dietary GSE in an in vivo model of human colon cancer, azoxymethane (AOM) was used to induce pre-neoplastic colonic lesions in male Fischer …
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Untersuchungen über Regulationsmechanismen der 11beta-Hydroxysteroid Dehydrogenase Typ 1
… und Insulinresistenz. Ihre Wirkung wird u.a. PPARgamma-abhängig vermittelt und kann durch das Inkretin (Glucose-dependent insulinotropic Peptide) GIP modifiziert werden. So wurden die Effekte von unterschiedlichen Fettsäuren, vom PPARgamma Agonisten Rosiglitazon sowie dem Inkretin GIP auf die …
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Progesterone Receptor Regulation of the Gene Networks That Control Ovulation in Mice
… proliferator-activator receptor gamma (PPARgamma), hypoxia-inducible factors (HIFs), and interleukin-6 (IL-6) as critical regulators of ovulation. These factors function as the downstream mediators of the PR signal to bring about the rupture of a mature ovarian follicle. The knowledge …
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
… suggested Hh signaling functioned upstream of PPARgamma . Mechanistic studies showed that Hh signaling might act as a molecular switch, likely mediated by anti-adipogenic transcrition factors such as GATA2, to divert preadipocytes as well as multipotent mesenchymal prescursors away from …
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
The transcriptional coactivator PPARgamma coactivator 1alpha (PGC-1α) is a regulator of mitochondrial biogenesis and function and is decreased in the striatum of patients with Huntington’s Disease (HD). HD is an autosomal dominant neurological disorder caused by a polyglutamine repeat in the …
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Role of Cyclin-Dependent Kinase Inhibitors in Estrogen Regulation of Adipogenesis
… factors like C/EBPbeta, C/EBPalpha, PPARgamma and Glut4. Wild-type (WT) mouse embryonic fibroblast (MEFs) had increased mitotic clonal expansion (MCE) due to lack of estrogen but this was not seen in p27KO MEFs, that showed that the effects due to these two pathways were not additive …
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The Effects of Feeding Growing Female Rats Different Sources of Omega-3 Polyunsaturated Fatty Acids on Lipogenic Gene Expression and Lipid Metabolism in Liver and Adipose Tissues
… oil source to alter lipolytic gene expression. PPARgamma was up-regulated in FO (P=0.04) compared to CO-fed rats. FO had the highest (P<0.05) EPA:DHA ratio in gonadal adipose tissue. All n-3 PUFA sources decreased lipogenesis, evidenced by decreased (P<0.05) serum high density lipoprotein …
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Effects of maturation, polyploidy, and nutrition on growth, composition, and gene expression within fatty acid metabolism in rainbow trout
… to be associated with increased expression of PPARgamma as well as altered expression within the mTOR pathway, consistent with continued deposition of lipids in these fish. A subsequent study examined differences in fatty acid composition and gene expression between immature male and female …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
<p>Hypertension is one of the common complications of obesity. Using a rat model of diet induced obesity and hypertension we investigated some of the mechanisms that are involved in regulation of blood pressure in obesity. The first aim of this study was to determine the role of proximal tubule …
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The Signaling Pathway of Oxysterol Induced Apoptosis in Chinese Hamster Ovary (CHO)-K1 Cells.
<p>Apoptosis, a form of genetically programmed cell death, plays a key role in regulation of cellularity of the arterial wall. During atherogenesis, improper apoptosis may cause abnormalities of arterial morphogenesis, wall structural stability, and metabolisms. It has been well established that …
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ANALYSIS OF ADULT NEUROGENESIS AND HIPPOCAMPUS-DEPENDENT MEMORY IN MOUSE MODELS FOR AGING, ALZHEIMER’S DISEASE AND CRANIAL IRRADIATION-INDUCED NEUROINFLAMMATION
Aging in the brain is a complex process that affects every living being differently. Age-associated memory decline can be mild; however, memory can deteriorate quickly with in patients with mild cognitive impairment or a significant brain injury. Investigating therapeutics that support learning and …