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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 27 for “"PPARg"”.

  1. Metabolic Regulation by Fibroblast Growth Factor 21

    Dutchak, Paul Anthony2011

    … was associated with increased SUMOylation of PPARg protein in this tissue. Using a feeding-fasting paradigm, I found that FGF21 expression in the liver and adipose tissue was rhythmic, peaking in liver prior to feeding and peaking in the adipose after feeding. Furthermore, the induction of …

    utswmed Repository record

  2. The role of the mitofusins in adipose tissue

    Mann, JakeUniversity of Cambridge2021

    … of lipid to wild-type cells, they showed reduced PPARG and GLUT4 expression with minimal insulin-stimulated glucose uptake. RNA sequencing revealed a pro-adipogenic transcriptional profile in Mfn1-/- MEFs including upregulation of PPARG. These findings were replicated using siRNA knock-down in …

    cambridge Repository record

  3. Biological role of conceptus derived factors during early pregnancy in ruminants

    Brooks, KelseyUniversity of Missouri--Columbia2016

    … activator receptors delta (PPARD) and gamma (PPARG) in the elongating conceptus; (3) the cortisol converting enzymes HSD11B1 and HSD11B2 in conceptus development; (4) the role of the glucocorticoid receptor (GR) in cortisol signaling during conceptus elongation. Gene knockout studies utilizing …

    missouri Repository record

  4. Untersuchungen zu Mutationen in Kandidatengenen für die Adipositas in einem Kollektiv von Patienten mit massivem Übergewicht

    Feldmann, DorisUniversität Würzburg

    … noch nicht beschriebene Mutation (V166I). 2) PPARg ist ein nukleärer Transkriptionsfaktor, der unter anderem die Genexpression im Rahmen der Adipozytendifferenzierung und Nährstoffspeicherung reguliert. In einem Kollektiv von Patienten mit extremer Adipositas wurde die Häufigkeit eines …

    wurz-thes Repository record

  5. Prediction Models and Pharmacogenomics in Adult Growth Hormone Deficiency

    Barbosa, Edna de Jesus Litenski2012

    … proliferator-activated receptor gamma (PPARG) gene with lower LDL-C and the APOE/C1/C4/C2 cluster with lower tryglicerides (TG). After GHRT, greater reductions in TC and LDL-C were associated with SNPs in the APOB and PPARG, explaining 5% of the variation. SNPs in the signal transducer …

    goteborg Repository record

  6. Dietary, Genetic and Metabolic Determinants of Serum Adiponectin

    Alsaleh, AseelKing's College London2012

    … polyunsaturated/saturated fatty acid ratio and PPARG Pro12Ala genotype on total and LDL cholesterol and plasma triacylglycerol concentrations. After a high monounsaturated fat diet, carriages of both PPARA Val162 and PPARG Ala12 alleles were associated with a greater reduction in plasma LDL-C …

    kings Repository record

  7. Enhanced care to people of South Asian Ethnicity-the United Kingdom Asian Diabetes Study (UKADS)

    Bellary, SrikanthUniversity of Birmingham2010

    … susceptibility genes with small effect sizes (PPARG, PPARG1A, CALPAIN10 ) were not adequately powered to detect possible associations.

    birmingham Repository record

  8. Cellular and Molecular Mechanisms Governing Intramuscular Fat Development and Growth in Cattle

    Tan, ZhendongVirginia Tech2025

    … expression of adipogenesis-related genes such as PPARG, ADAM12, and PPARGC1A. Together, the findings from the second study reveal two key differences in APCs between IMF and SF: (1) IMF contains fewer APCs than SF and (2) IMF-derived APCs are less differentiated, providing a plausible explanation …

    vt Repository record

  9. Distinct Functional Properties of Perinatal Versus Adult Adipose Progenitor Subpopulations

    Zhang, Qianbin2022

    … I found that transient overexpression of Pparg in PDGFRβ+ cells only during postnatal day 0.5 to 7.5 leads to hyperplastic WAT development, durable progenitor cell reprogramming, and protection against pathologic wat remodeling and glucose intolerance in adult-onset obesity. Thus, factors …

    utswmed Repository record

  10. Identification of Anti-inflammatory and Antioxidant Properties of MangostinXanthones in Adipocyte Reporter Assays

    Shen, QiwenThe Ohio State University2013

    … gene <i>Fabp4</i>, and Nrf2, an inducer of <i>Pparg</i> expression. The screening in <i>Nrf2</i>-P/YFP adipocytes suggested that α-MG effectively and dose-dependently reduced <i>Nrf2</i> promoter activation, whereas <i>Fabp4</i> promoter activation was not influenced. Thus, the antioxidant …

    ohiolink Repository record

  11. Exploring the Grey Zone between Type 1 and Type 2 Diabetes

    Bakhtadze, EkaterineDepartment of Clinical Sciences, Lund University2009

    … I and II), PTPN22, Ins VNTR, TCF7L2 (study II), PPARG, KCNJ11, IGF2BP2, WFS1, CDKAL1, JAZF1, CDKN2A/2B, HHEX, SLC30A8 and FTO (study III) and MODY genes- HNF-4 , GCK, HNF-1 and HNF-1ß, formerly TCF2 (study IV), measured islet antibodies (ICA, IA-2A and GADA) and C-peptide (marker of beta-cell …

    lund Repository record

  12. Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways

    Wu, HaiUT Southwestern Medical Center2002

    … mediated through the upregulation of PGC-1 (PPARg co-activator). Taken together, these findings delineate a molecular pathway in which MEF2 and NFAT integrate signaling inputs from multiple calcium-regulated pathways in the control of skeletal muscle fiber types.

    utswmed Repository record

  13. Genetic association between schizophrenia and type-2 diabetes

    Mathur, AditiUniversity of Edinburgh2011

    … proliferator activated receptor-gamma (PPARG), phospholipid A2, group IVA (PLA2G4A), prostaglandin-endoperoxide synthase 2 (PTGS2) and v-akt murine thymoma viral oncogene homolog 1 (AKT1). The Haploview™ program was applied to check Mendelian errors, to test Hardy-Weinberg equilibrium …

    uhi-uk Repository record

  14. Molecular Mechanisms Governing the Pharmacology of LDT409 for the Treatment of Metabolic Disease

    Sahin, Cigdem2023

    … with potent and balanced affinity for PPARa and PPARg and weak binding affinity to PPARδ (Chapter 2). Moreover, we assessed that chronic treatment with LDT409 was effective at reversing diet-induced obesity and its complications in mice. LDT409 exhibited metabolically beneficial effects on …

    toronto-retro Repository record

  15. INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE

    AURILIA, MIRIAMUniversità degli Studi di Milano2025

    … mitochondrial respiration, activating the PPARG pathway, and inducing the expression of FOX3a, a transcription factor involved in the transcriptional activation of autophagy. Indeed, ESRRA inhibition enhances cellular clearance by boosting autophagic flux by mechanism independent of the …

    milano Repository record

  16. Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome

    Vasquez, Yelkaira2020

    … prevented. In contrast, activators of PPARa and PPARg are effective in lowering blood lipids and sugar and have been considered useful in the treatment of obesity and diabetes. Like the PPARs, LXR suppresses production of inflammatory mediators in a manner reciprocal to its regulation of lipid …

    mississippi Repository record

  17. Regulation of milk fat synthesis by dietary fatty acids

    Kadegowda, Anil Kumar Gopalapura2008

    … (TF) SREBP-1C. Potential roles of the TF ChREBP, PPARG, and INSIG1 were also established. A subsequent study aimed to establish whether these mechanisms operated in lactating dairy cows. Compared with un-infused controls and a t10c12 CLA negative control, post-ruminal infusion of butterfat which …

    maryland Repository record

  18. Mechanisms underlying enhanced bone marrow adipogenesis in diabetes

    Kum, Jina J.Y.The University of Western Ontario2021

    … proliferator-activated receptor gamma (PPARG) in diabetic mice. My results showed that adipogenesis inhibition prevents lipid accumulation in the liver of diabetic mice but does not affect the enhanced adipogenesis in the bone marrow. Taken together, my studies identified enhanced bone …

    uwo Repository record

  19. An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome.

    Bhatta, PrabhakarRobert Gordon University2018

    … proliferatoractivated receptorγ coactivator1 (PPARGC1A) gene and its relation to risk of type 2 diabetes has been studied in the United Kingdom population. A metaanalysis of genetic variant rs8192678 (Gly482Ser) of peroxisome proliferatoractivated receptorγ coactivator1 (PPARGC1A) gene and its …

    rgu Repository record

  20. Testes de nutrigenética: aplicações na prevenção e tratamento da obesidade

    Duarte, Mychelle Kytchia Rodrigues NunesUniversidade Federal do Rio Grande do Norte2024

    … NT marketed in Brazil, only ADIPOQ rs17300539, PPARG rs1801282 were associated with overweight and obesity; SOD rs4880 was related to protection against overweight and obesity. Thus, it was shown that more studies are needed to validate which SNP are related to overweight and obesity in the …

    brazil-ufrn Repository record

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