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Showing 1 to 1 of 1 for “"PPARalpha, Polymorphism, Flavonoids, Botannical, NCoR, V227A"”.
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Discovery of botanical flavonoids as dual peroxisome proliforator, activated receptor (PPAR) ligands and functional characterization of a natural PPAR polymorphism that enhances interaction with nuclear compressor
Our data suggest that the PPARalpha/NCoR interaction is physiologically relevant, and can produce a discernable phenotype when the magnitude of the interaction is altered by a naturally occurring variation. Our detailed mechanistic study of the PPARalpha V227A variant allows for the design of …