Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PPARalpha"”.
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Peroxisome Proliferator -Activated Receptor (Ppar)alpha Regulation of Highly Unsaturated Fatty Acid Synthesis
The aim of the subsequent study was to identify a PPARalpha ligand under EFA deficiency. Lysophospholipids (lysoPL) are the most likely candidates for the ligands because decreased HUFA under EFA deficiency may shift the equilibrium of phospholipid deacylation/reacylation cycle toward accumulation …
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Regulation of Highly Unsaturated Fatty Acid Metabolism
… proliferators activated receptor alpha (PPARalpha) and sterol regulatory element binding protein (SREBP)-1, are considered as the main regulators of fatty acid oxidation and synthesis, respectively, including metabolism of highly unsaturated fatty acids (HUFAs). The objective of the first …
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Discovery of botanical flavonoids as dual peroxisome proliforator, activated receptor (PPAR) ligands and functional characterization of a natural PPAR polymorphism that enhances interaction with nuclear compressor
Our data suggest that the PPARalpha/NCoR interaction is physiologically relevant, and can produce a discernable phenotype when the magnitude of the interaction is altered by a naturally occurring variation. Our detailed mechanistic study of the PPARalpha V227A variant allows for the design of …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to pathogenicity in …
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The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… activated receptor alpha, delta and gamma (PPARalpha, delta and gamma) were expressed by OA chondrocytes and osteocytes in the underlying bone, with a decrease in GPR18, TPRV1 and PPAR in specific zones of the osteochondral compartment associated with an increase in grade of …
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Ursachen und Folgen vermehrter Expression des nukleären Rezeptors Constitutiver-Androstan-Rezeptor (NR1I3) durch Agonisten des nukleären Rezeptors Peroxisomenproliferator-aktivierter-Rezeptor-alpha (NR1C1)
Der Fettsäurestoffwechsel unterliegt vielfältigen Kontrollmechanismen. So wird der Fettsäureabbau über die Induktion und Aktivität spezifischer Enzyme reguliert. Ein zentraler Regulator ist dabei der nukleäre Rezeptor Peroxisomenproliferator-aktivierter-Rezeptor-α (PPARα). PPARα wird durch freie …
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Fatty acid regulation of adhesion molecule expression in human vascular cells.
… factor, PPARy DNA binding activity, but not PPARalpha, was significantly increased by CLA, a known PPAR agonist. The results demonstrate that n-3 PUFA and CLA are able to alter the DNA binding activity of transcription factors to differing extents. Oxidative stress is another factor that is …