Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"PPAR-gamma"”.
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Functional genomic analysis of PPAR-gamma in human colorectal cancer cells
The gamma isoform of peroxisome-proliferator activated receptor (PPAR-gamma) is a member of the super family of nuclear hormone receptors and shows much promise as a chemopreventative and therapeutic target for colorectal cancer. Activation of PPAR-gamma by thiazolidinediones (TZDs) inhibits …
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Defining Novel Clusters of PPAR gamma Partial Agonists for Virtual Screening
Peroxisome proliferator-activated receptor γ (PPARγ) is associated with a wide range of diseases, including type 2 diabetes mellitus (T2D). Thiazolidinediones (TZDs) are agonists of PPARγ which have an insulin sensitizing effect, and are therefore used as a treatment for T2D. However, TZDs cause …
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Mechanistic Studies Of A Novel Ppar-Gamma Mutant That Causes Lipodystrophy And Diabetes
<p>PPAR-gamma is a nuclear receptor that plays a central role in metabolic regulation by regulating extensive gene expression networks in adipose, liver, skeletal muscle and many other tissues. Human PPAR-gamma mutations are rare and cause a monogenetic form of severe type II diabetes with …
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Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
Peroxisome proliferator activated receptor gamma (PPARγ) is a ligand-modulated transcription factor belonging to the nuclear receptor superfamily. PPARγ regulates genes involved in adipocyte differentiation, insulin homeostasis, neuroprotection and anti-inflammation. As such, PPARγ is under …
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Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand activated transcription factors. There are three identified isotypes: PPAR alpha, PPAR gamma and PPAR delta, together controlling the expression of genes involved in inflammation, cell differentiation, …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
OBJECTIVE: To investigate the role of ERK and PPAR gamma on TGF-β1-induced human endometrial stromal cell decidualization in vitro. MATERIALS AND METHODS: Human endometrial tissues obtained by hysterectomy specimens from patients with conditions other than endometrial diseases such as leiomyoma. …
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and …
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SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
… has been shown to be a negative regulator of PPAR[gamma] and NF[kappa]B, two transcription factors important for the differentiation of osteoblasts and osteoclasts, respectively. Here, we show that SirT1 is an important regulator of bone mass in vivo: SirT1 whole-body knockout mice display …
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Genotoxic effects of a novel form of Gold Nanoparticles loaded with Hesperidin on head and neck cancer lymphocytes compared to effects from healthy control lymphocytes and Squamous cell Carcinoma of Maxillary sinus
… by up-regulating the expression of p53, p21, PPAR gamma, and Caspase 3, at mRNA and protein levels by up-regulating the p53, PPAR gamma, Caspase 3, and p21 to mediate apoptosis and DNA repair in MC cells. The findings of this study are consistent with the view that the Hsp-AuNPs could have a …
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Genotoxic effects of a novel form of Gold Nanoparticles loaded with Hesperidin on head and neck cancer lymphocytes compared to effects from healthy control lymphocytes and Squamous cell Carcinoma of Maxillary sinus
… by up-regulating the expression of p53, p21, PPAR gamma, and Caspase 3, at mRNA and protein levels by up-regulating the p53, PPAR gamma, Caspase 3, and p21 to mediate apoptosis and DNA repair in MC cells. The findings of this study are consistent with the view that the Hsp-AuNPs could have a …
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Effects of dietary macronutrient composition and exogenous neuropeptide Y on adipose tissue development in broiler chicks
… peroxisome proliferator-activated receptor gamma (PPAR gamma) and sterol regulatory element-binding transcription factor 1 (SREBP1) mRNAs in chicks fed the HF diet, whereas there was an increase in SREBP1 expression in chicks fed the HF diet after NPY injection. Expression of PPAR gamma and …
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Comparison of human and mouse AKR1C enzymes: implications for modeling human cancer
… peroxisome proliferator-activated receptor \(\gamma\) (PPAR\(\gamma\)) suggesting a new form of signaling is involved. This discovery has implications in the interplay between inflammation, where high levels of PGD2 are secreted, and adult muscle regeneration, two processes that are intimately …
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Regulation of Phosphorylation of PPARγ by CDK5 in Obesity
PPAR? is the receptor for thiazolidinedione (TZD) anti-diabetes drugs, and a key regulator of adipose differentiation and insulin sensitivity. Increased heart failure associated with specific TZDs has reduced their clinical use. However recent work suggested that phosphorylation of PPAR? at Ser273 …
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Expression et fonction d'ACSL4 dans les glioblastomes
… activés par les proliférateurs de peroxysomes (PPAR) gamma augmente l’expression de la protéine ACSL4 exprimée dans les lignées GBM. L’étude en composition d’acides gras cellulaires a révélé que les tissus de cerveau non cancéreux contenaient une importante quantité d’AGPI dont le DHA en …
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The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
Fuel acquisition is essential to survival. During privation, the body protects glucose concentrations acutely by glycogenolysis, and later by gluconeogenesis and ketogenesis. Additionally, animals alter daily behavioral patterns to seek food, but eventually reduce energetically costly activities …
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A Study on the Effect of Peroxisome Proliferator-Activated Receptors (PPARs) Activation in Cultured Rat Brain Glial Cells
"The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which were originally known to be involved in the regulation of lipid and glucose homeostasis. Recently, there has been increasing reports on the involvement of PPARs during inflammatory process, but the exact …
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Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust
… peroxisome proliferator activated receptor γ (PPARγ) nuclear receptor. To date, very few chemicals have been identified as possible PPAR ligands. In the thesis, our goal was to determine the PPARγ ligand binding potency and activation of several groups of major semi-volatile organic compounds …
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Effects of dietary fat and protein from corn coproducts on growth, carcass characteristics, ruminal metabolism, and genomic regulation of marbling development in early-weaned beef cattle
… which increased (P < 0.01) gene expression of PPAR gamma, insulin induced gene 1, thyroid hormone responsive SPOT14 protein, ATP citrate lyase, adiponectin, diacylglycerol O-acyltransferase homologue 2, fatty acid binding protein 4, fatty acid synthase, phosphoenolpyruvate carboxykinase 1, and …
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Effect of Nedd4 Haploinsufficiency on Insulin Sensitivity, Adiposity and Neuronal Behaviors
… peroxisome proliferator-activated receptor gamma (PPARγ) in Nedd4- haploinsufficient mice in the WAT. Downregulation of NEDD4 in 3T3-L1 preadipocytes impaired the adipogenic response, resulting in decreased PPARγ expression. Thus, the reduced adiposity in Nedd4-haploinsufficient mice fed a …