Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PPAR-alpha"”.
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Peroxisome Proliferator -Activated Receptor (Ppar)alpha Regulation of Highly Unsaturated Fatty Acid Synthesis
The aim of the subsequent study was to identify a PPARalpha ligand under EFA deficiency. Lysophospholipids (lysoPL) are the most likely candidates for the ligands because decreased HUFA under EFA deficiency may shift the equilibrium of phospholipid deacylation/reacylation cycle toward accumulation …
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Dry Period Nutrition and Hepatic Metabolism of Fatty Acids and Glucose in Transition Dairy Cows
… of peroxisome proliferator activated receptor-alpha (PPAR-alpha) agonists on oxidation of palmitate by liver slices. The response by liver slices to both natural and synthetic PPAR-alpha agonists was intriguing and led to applications in vivo. In experiment 4, male Holstein calves were treated …
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Systems biology of diet-induced hepatic insulin resistance
… gene expression changes and found roles for PPAR[alpha] and RXR[alpha]. We performed ChIP-Seq experiments for these factors and treated mice and primary hepatocytes with a PPAR[alpha] activator, uncovering a role for PPARα in the regulation of anaerobic glycolysis. We also validated novel …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… peroxisome proliferator-activated receptor alpha (PPAR alpha ) and retinoid X receptor (RXR). Thus, cholesterol absorption can be regulated by nuclear receptor modulation of NPC1L1 expression.
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Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand activated transcription factors. There are three identified isotypes: PPAR alpha, PPAR gamma and PPAR delta, together controlling the expression of genes involved in inflammation, cell differentiation, …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to pathogenicity in …
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A Study on the Effect of Peroxisome Proliferator-Activated Receptors (PPARs) Activation in Cultured Rat Brain Glial Cells
"The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which were originally known to be involved in the regulation of lipid and glucose homeostasis. Recently, there has been increasing reports on the involvement of PPARs during inflammatory process, but the exact …