Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"PPAR-agonists ,"”.
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
Peroxisome proliferator-activated receptors (PPARs) belong to a nuclear receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and …
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P53 Dimers Elicit Unique Tumor Suppressive Activities Through An Altered Metabolic Program
… upregulate a novel transcriptional program of PPAR activation. These activities are associated with lower prevalence of thymic lymphomas and inhibition of immature CD8+ T cell accumulation. Lymphomas derived from dimeric p53 mice show cooperating genomic alterations including those in the PPAR …
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Refinement of the Docking Component of Virtual Screening for PPAR
… proliferator-activated receptor-gamma (PPAR") as a drug target holds applications for treating a wide variety of chronic inflammation-related diseases. Type 2 diabetes (T2D), which is a metabolic disease influenced by chronic inflammation, is quickly reaching epidemic proportions. …
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Molecular Mechanisms Governing the Pharmacology of LDT409 for the Treatment of Metabolic Disease
… The peroxisome proliferator-activated receptors (PPARa/g/b) are fatty acid sensors that play important roles in the regulation of lipid metabolism and glucose homeostasis. Herein, we report the characterization of novel compounds derived from phenolic lipids that are abundant in cashew nut shell …
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Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2
… docking studies predicted that ABA and other PPAR - agonists share a binding site on the surface of LANCL2. In Chapter 3 of the dissertation, structure-based virtual screening was performed. Several potential ligands were identified using molecular docking. In order to validate the …
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Der Einfluß von Pioglitazon auf den Lipoproteinstoffwechsel bei Patienten mit arterieller Hypertonie und normalem Glukose-Haushalt
Der Einfluss von Pioglitazon auf den Lipoproteinstoffwechsel bei Patienten mit arterieller Hypertonie und normalem Glukose-Haushalt.