Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"PPAR-γ"”.
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Endometrial Decidualization by TGF-β and PPAR-γ
… so we investigated the interaction of TGF-β and PPAR-γ on decidualization using cultured human endometrial stromal cell. METHODS: Human endometrial tissues were examined immunohistochemically for the expression of TGF-β receptors and transducer proteins in the TGF-β signaling. And we examined the …
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The Effects of PPAR-γ Activators on the Growth and Apoptosis of Melanocytes
… Peroxisome proliferator-activated receptors (PPARs) play an important role in cellular responses including proliferation and differentiation. It was reported that 3 subtypes of PPAR are expressed in human melanocytes and activators for PPAR-α and PPAR-γ modulates melanocyte growth and …
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Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: Importance of peroxisome proliferator-activated receptor γ expression
… peroxisome proliferator-activated receptor γ (PPAR-γ) in intestinal epithelial and immune cells. Dietary spingomyelin decreased colonic inflammation in mice of both genotypes but more efficiently in mice expressing PPAR-γ. Using a real-time polymerase chain reaction array, we detected an …
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Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
… via Peroxisome Proliferator-Activated Receptor (PPAR)-γ in inflammatory disorders such as Crohn's Disease and Inflammatory Bowel Disease. We sought to determine whether CLA isomers would reduce inflammation via PPAR-γ in cultured mesangial cells, and in murine models of anti-glomerular basement …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… proliferator activated receptor-gamma (PPAR-γ), a master transcriptional regulator of adipogenesis, was downregulated during EMT process. Downregulation of PPAR-γ in breast cancer cells enhances cell migration, colony formation, and chemotherapy resistance indicating PPAR-γ has critical …
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Using Genetic Epidemiologic Methods to Explore the Influence of Gene-Environment Interactions on Colorectal Adenoma Recurrence
… interactions between allelic variation in PPAR-γ (Pro12Ala, C1431T), body mass index (BMI) and waist circumference, and the biochemical biomarkers of metabolic syndrome. Simulated data were then used to determine if the sample size required to formally test the relationship between …
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Intracellular signalling by arachidonic acid metabolites
… peroxisome proliferator activated receptor (PPAR)-γ, the activities of PPARs were assessed using JEG3 cells transfected with a PPAR-response element reporter construct (pTK-PPREx3-luc). The PPAR-γ-specific ligand, rosiglitazone, induced PPRE mediated activity in a concentration-dependent …
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Nuclear receptor co-repressor actions in bladder cancer
… anti-proliferative responses to FXR, VDR and PPAR-γ ligands in NCoR1 over-expressing cells; confirmed as a G1/S phase cell cycle arrest in EJ-28. Microarray profiling revealed unique regulation of genes involved in cell proliferation. This study suggests NCoR1 acts as a selective regulator of …
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Characterisation of an immune-modulating peptide secreted by a helminth worm
… activity was mediated through the activation of PPAR-γ pathways. This is the first report of a PPAR-γ agonist being secreted by a helminth parasite as a mechanism of modulating mammalian innate immune responses. Importantly, a homologous parasite peptide from a related trematode parasite …
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Alcohol/HIV-Induced Neurodeficit and Circumvention by Neuroprotective Agent
… of peroxisome proliferator activated receptor (PPAR) agonist on its ability to help alleviate the neurodeficit caused by Tat. The animals completed the described behavior battery above allowed us to identify the drug effects and potential changes in sex difference. In Chapter 1, we introduce the …
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Regulation of milk fat synthesis by dietary fatty acids
… (TF) SREBP-1C. Potential roles of the TF ChREBP, PPARG, and INSIG1 were also established. A subsequent study aimed to establish whether these mechanisms operated in lactating dairy cows. Compared with un-infused controls and a t10c12 CLA negative control, post-ruminal infusion of butterfat which …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… proliferator-activated receptor gamma (PPAR-γ) and tight junction protein zonula, occludin (ZO-1). Further, in newly diagnosed IBD patients, PKM2 was indicative of disease presence with less variation than other biomarkers like fecal calprotectin and fecal lactoferrin. Lastly, altered …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Coactivator-1 β (PGC-1β) and PGC-1-Related Coactivator (PRC) to promote mitochondrial biogenesis, while also inducing the mitophagy receptor B-cell Lymphoma 2 (BCL-2)/Adenovirus E1B 19 kDa Protein-Interacting Protein 3 (BNIP3). IGF-1 also …
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The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… via inhibition of lipid droplet accumulation, PPAR-γ, and C/EBP-β expression. Also poncirin prevented osteoclast differentiation via inhibition of TRAP-positive MNCs, and regulation of OPG/RANKL ratio. During mesenchymal stem cell differentiation, DEX inhibited osteoblast differentiation …
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FUNCTIONAL CHARACTERIZATION OF THE INTERACTION BETWEENP. AERUGINOSA AND DENDRITIC CELLS TRIGGERING THE DIFFERENTIATION OF PATHOGENIC TH1/17 CELLS IN CYSTIC FIBROSIS.
… dei fattori di trascrizione CEBP-δ e PPAR-γ, coerentemente con i risultati dall’analisi trascrittomica. Nel complesso, i nostri risultati indicano che i ceppi clinici di Pa promuovono la generazione dei linfociti co-produttori di IFN-γ/IL-17 patogenici, inducendo inoltre una …
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Chemical Tools for Exploring Metabolite Interactions with Nuclear Receptors and Beyond
… of peroxisome proliferator–activated receptor (PPAR) γ. We also explore repurposing alk-GW9662. We profile its target proteins using chemical proteomics and demonstrate that the probe can be used in target engagement study of other proteins. Overall, our results suggest that alk-GW9662 may be …
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Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… of COL1A1, COL3A1, MMP1, MMP2, TIMP1 and PPAR-γ mRNA (qPCR). Cells from the stromal vascular fraction (SVF) were cultured and characterised by immunocytochemistry and compared to human preadipocytes sourced commercially. The secretion of FGF, adiponectin and VEGF by the preadipocyte and …
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Assessment of blue whiting protein hydrolysate bioactivities using cell culture models
… (peroxisome proliferator activated receptor (PPAR)-γ and CAAT (controlled amino acid therapy)/ enhancer binding protein (C/EBP)-α) compared with the differentiated controls (p<0.05). These SGID hydrolysates also exhibited anti-obesity activities following simulated intestinal permeation. After …
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Τα συστατικά στοιχεία του συστήματος λιπιδίων και λιποπρωτεϊνών ως κεντρικοί ρυθμιστές στην εμφάνιση της παχυσαρκίας και της μη αλκοολικής λιπώδους νόσου του ήπατος σε πειραματικά μοντέλα ποντικών
… του mRNA των γονιδίων FASN, DGAT-1 και PPAR-γ απέκλεισε την de novo σύνθεση των λιπαρών οξέων και των τριγλυκεριδίων σαν πιθανή αιτία της εμφάνισης της νόσου στα apoA-I-/- ποντίκια. Παρόμοια το μεταβολικό προφίλ δεν ανέδειξε σημαντικές διαφορές στην ενεργειακή δαπάνη μεταξύ των apoA-I-/- …