Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"PPARγ"”.
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Regulation of Phosphorylation of PPARγ by CDK5 in Obesity
PPAR? is the receptor for thiazolidinedione (TZD) anti-diabetes drugs, and a key regulator of adipose differentiation and insulin sensitivity. Increased heart failure associated with specific TZDs has reduced their clinical use. However recent work suggested that phosphorylation of PPAR? at Ser273 …
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PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
… activated receptor gamma (PPARγ) agonist rosiglitazone improves hippocampus-dependent cognitive deficits in some AD patients and ameliorates deficits in the Tg2576 mouse model for AD amyloidosis. Since extracellular signal-regulated protein kinase mitogen-activated protein …
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PPARγ agonism attenuates cocaine seeking behavior via association with ERK MAPK
… cocaine use and abstinence. Our lab demonstrated PPARγ agonism rescued cognitive impairment in an animal model of Alzheimer’s disease and that this rescue involved ERK. Given the role of altered learning and memory circuitry in addiction, and our recent evidence that PPARγ is involved in restoring …
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Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents
… peroxisome proliferator-activated receptor γ (PPARγ). We pursued a gene knockout strategy to identify the LPA receptor subtypes necessary for the neointimal response in a non-injury model of carotid remodeling and also compared the effects of AGP and the PPARγ agonist rosiglitazone (ROSI) on …
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… through potential interactions with PPARγs, canonical WNT proteins, and estrogen receptors (ER) signaling. The current investigation was conducted to test the effects of synthetic and natural estrogenic compounds (BDDA, daidzein, and genistein) for their effects on the induction of …
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Μορφολογική εκτίμηση της συνομιλίας (cross–talk) των μεταγραφικών παραγόντων PPARγ και AP-1 στην καρκινογένεση του παχέος εντέρου
… των μεταγραφικών παραγόντων AP-1, NF-κB και PPARγ στην καρκινογένεση του παχέος εντέρου δεν είναι πλήρως εξακριβωμένος. Είναι γνωστό ότι ο υποκινητής του γονιδίου cox-2 περιλαμβάνει περιοχές πρόσδεσης των μεταγραφικών παραγόντων AP-1 και NF-κB. ΣΚΟΠΟΣ Με σκοπό την διερεύνηση του ρόλου των …
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Effekte des oxidativen Stresses auf die Expression der Scavenger-Rezeptoren CD36 und SR-BI und des Transkriptionsfaktors PPARγ in Makrophagen
… CD36, SR-BI, des Transkriptionsfaktors PPARγ und pro-inflammatorischer Zytokine zu untersuchen. Die durchgeführten Untersuchungen beruhen auf der Annahme, dass modifizierte LDL durch Induktion der genannten Scavenger-Rezeptoren und nachfolgende unregulierte Aufnahme in Makrophagen mit …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… proliferator-activated receptor gamma (PPARγ) is expressed in microglia and peripheral immune cells, where it is involved in macrophages polarization and in the control of inflammatory responses, by modulating gene transcription. Several studies have shown that PPARγ agonists are …
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Anticonvulsant effects of PPAR-gamma activation in an in vitro model of seizure
Peroxisome proliferator activated receptor gamma (PPARγ) is a ligand-modulated transcription factor belonging to the nuclear receptor superfamily. PPARγ regulates genes involved in adipocyte differentiation, insulin homeostasis, neuroprotection and anti-inflammation. As such, PPARγ is under …
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EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… proliferator-activated receptor gamma (PPARγ), oxidative stress, and/or endoplasmic reticulum (ER) stress, known pathways of lignan and TKI action. A standard PPARγ competitive binding assay was conducted to assess whether three multi-target TKIs and ENL were PPARγ agonists. Binding …
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Defining Novel Clusters of PPAR gamma Partial Agonists for Virtual Screening
Peroxisome proliferator-activated receptor γ (PPARγ) is associated with a wide range of diseases, including type 2 diabetes mellitus (T2D). Thiazolidinediones (TZDs) are agonists of PPARγ which have an insulin sensitizing effect, and are therefore used as a treatment for T2D. However, TZDs cause …
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Mechanisms of Post-hemorrhagic Hydrocephalus after Germinal Matrix Hemorrhage
… cerebrospinal fluid circulation and absorption. PPARγ stimulation enhances micgroglial/macrophage phagocytosis of erythrocytes via CD36 scavenger receptor, augmenting clot resolution and improving outcomes after adult cerebral hemorrhage. Additionally, lysed erythrocytes and metabolized …
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Development and Characterization of Pre-Clinical Epilepsy Models to Evaluate Potential Anti-Seizure Targets.
… models to evaluate ser273 phosphorylation of PPARγ as a potential anti-seizure target. We find that seizures are closely associated with increased ser273 phosphorylation of PPARγ. We also find dysregulation in gene transcription of PPARγ regulated histone deacetylates (SIRT3), anti-oxidants …
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The Influence of Growth Stage on Carcass Composition and Factors Associated with Marbling Development in Beef Cattle
… peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein β, and myostatin. Carcass data were recorded and LM samples were collected and aged 2, 7, 14, and 21 d postmortem for Warner-Bratzler shear force (WBSF) determination. Carcass composition was estimated by …
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Development of Therapies to Treat Polycystic Kidney Disease
… expected. Previous studies demonstrated that PPARγ agonists, insulin sensitizing drugs used to treat diabetes, inhibit chloride secretion by the collecting duct principal cells by decreasing CFTR synthesis. It was logical therefore to considered PPARγ agonists as long-term treatment for PKD. …
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Avaliação do perfil de citocinas séricas e efeito imunomodulador in vitro de um novo derivado tiazolidínico LPSF/JB-20 em pacientes portadores de espondilite anquilosante
… Estudos com pacientes EA identificaram que o PPARγ pode atuar como um mediador provável dos efeitos das citocinas durante a inflamação e no processo de remodelação óssea. Os derivados tiazolidínicos (TZDs) vêm sendo estudados por atuar como agonistas PPARγ. Diante desse contexto nosso trabalho …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… peroxisome proliferator activated receptor γ (PPARγ) has reduced expression and activity in the kidney of OP vs. OR rats. Therefore, in the second aim we investigated the effect of PPARγ ligand activation on expression and activity of proximal tubule Na+ transporters in OP and OR rats. In …
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Function and activation of human adipose tissue: The role of genes in the link between physical activity and brown adipose-like phenotype
… proliferatoractivated receptor alpha (PPARα) and PPARγ genes with physical activity levels in WAT of healthy men (study 2); c) to examine the effects of different types of exercise and de-training on the UCP1 mRNA and protein expression (study 3), and d) on leptin mRNA in WAT of healthy men (study …
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Charakterisierung von Epidermis-Typ-Lipoxygenasen mit besonderer Berücksichtigung der e-LOX-3
… der Kontrolle der Synthese eines Liganden für PPARγ, einem Schlüsselfaktor der späten Fettzelldifferenzierung, zugesprochen. Die Bildung dieses Faktors, der in das Medium abgegeben wird, kann durch LOX-Inhibitoren unterdrückt werden. Als dafür verantwortliche LOX wurde in beiden Zellinien die …
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Altered regulation of adipogenesis with respect to disease processes
… 3T3-L1 differentiation. Investigation of PPARγ levels indicate that this enhanced adipogenesis is mediated through the stabilization of the PPARγ protein at specific time points during differentiation. The results demonstrate that ITM2A knockdown is sufficient to rescue the inhibitory …
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