Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"PPARα"”.
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Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα
… peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To determine whether there is an interaction between PPARα and nAChRs in VTA DA cells: particularly, to characterize the postsynaptic effects of PPARα …
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THE ANTI-INFLAMMATORY AND PRO-NEUROGENIC ROLE OF PPARα IN MODULATING RADIATION-INDUCED BRAIN INJURY
… properties. We hypothesize that activation of PPARα will prevent radiation-induced brain injury, in part, by inhibiting the radiation-induced inflammatory responses in the microglia and by preventing the WBI-induced decrease in hippocampal neurogenesis. For our in vitro studies, we hypothesized …
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Investigating the role of transcription factors Nrf2 and Pparα in hepatic lipid metabolism during fasting
… lipogenesis, which are known to be regulated by Pparα, are upregulated, indicating a potential role for Nrf2 in the repression of Pparα, a master regulator of hepatic lipid metabolism.<br/><br/>The primary aim of this thesis was to further define the role of Nrf2 during metabolic stress and to …
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Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia
… proliferator-activated receptors alpha (PPARα) are widely expressed in the brain and are activated by endogenous ligands like the fatty acid amides N-palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Recent studies have been published on PPARα mediated behavioral effects, which …
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Ursachen und Folgen vermehrter Expression des nukleären Rezeptors Constitutiver-Androstan-Rezeptor (NR1I3) durch Agonisten des nukleären Rezeptors Peroxisomenproliferator-aktivierter-Rezeptor-alpha (NR1C1)
… Peroxisomenproliferator-aktivierter-Rezeptor-α (PPARα). PPARα wird durch freie Fettsäuren in der Zelle aktiviert und fördert über die Induktion von Zielgenen den Fettsäuretransport und -abbau sowie die Gluconeogenese und Ketogenese. Der Anstieg an freien Fettsäuren beim Fasten, aber auch im …
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
… receptor superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and prompted investigation into the efficacy of PPAR agonists in …
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Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue
… was required for the induction of PGC1α, PPARα, PDK4 and UCP1 by β3-AR activation in BAT of mice. Similarly, lipolysis was required for the maximal induction of oxidative genes in cultured brown adipocytes (BAs), while increasing endogenous FAs elevated their expression. Pharmacological …
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Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
… the activity of lipid-sensing nuclear receptors PPARα and constitutive androstane receptor (CAR), which was evident by the increase in the expression of their respective target genes, PLIN2 and CYP2B6; however, farnesol had no effect on FXR activity in HepaRG cells. Gene expression analysis …
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Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
… peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor implicated in lipid metabolism, inflammation, and cancer biology. While their anti-tumour potential has been suggested in various malignancies, their role in human neuroblastoma (NB) remains unexplored. NB, a paediatric …
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Marine microbial co-cultivation and the production of novel bioactive secondary metabolites for drug discovery
… against the disease biomarkers; HDAC6, EL and PPARα. A total of 14 metabolites were isolated and structures were elucidated, seven of which are new metabolites not previously described, with six from bioactive fractions. A notable discovery was that of a novel proline-rich peptide SBT681/SBT017 …
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Function and activation of human adipose tissue: The role of genes in the link between physical activity and brown adipose-like phenotype
… peroxisome proliferatoractivated receptor alpha (PPARα) and PPARγ genes with physical activity levels in WAT of healthy men (study 2); c) to examine the effects of different types of exercise and de-training on the UCP1 mRNA and protein expression (study 3), and d) on leptin mRNA in WAT of healthy …
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
… pathways. The brown and white adipose tissue of PPARα-knock-out mice were also studied by lipidomic tools to get a deeper understanding of the effect of the peroxisome and PPAR system on adipose tissue and lipid metabolism during obesity. Most of the lipids were increased and became more …
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Crebh, A Novel Liver Clock Keeper For Energy Metabolism
… with, the circadian transcriptional activators PPARα and C/EBPβ or the repressor E4BP4 to modulate CREBH transcriptional activities. CREBH deficiency leads to hyper-locomotion, increased metabolic rates, and phase-shifted feeding behavior in mice. In summary, our studies reveal that CREBH …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
… secretions, and inhibition of both FFAR4 and PPARα blocked B. breve NCFB 2258 secretion-evoked calcium signalling. Interestingly, exposure of cells to B. breve supernatants in the presence of IL-6R antagonist resulted in significant GLP-1 secretion. Conclusion: Our work has shown that B. breve …
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Mechanisms into the development of fatty liver disease: role of bile acids, Betaine and MHY908
… for NAFLD such as bile acids, betaine and a PPARα/γ dual agonist MHY908. Method: Human hepatoma cell line, VL17A cells were treated with saturated fatty acid palmitic acid (PA) with a range of concentrations between 10 μM - 300 μM for 24 h, 48 h and 72 h after which lipid accumulation, cell …
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Impaired ketogenesis is implicated in intestinal stem cell function and epithelial regeneration in ulcerative colitis
… production is reduced in active UC. We identify PPARα, a known key inducer of HGMCS2 transcription as being significantly downregulated in UC. We find HGMCS2 expression and βHB production can be restored in UC organoids via administration of PPARα agonist, fenofibrate. We performed scRNA-seq of …
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Identifying a role for the scaffolding protein IQGAP1 in liver health and disease
… diet feeding, which is associated with impaired PPARα activation and hyperactive mTORC1 signaling. Furthermore, in chapter 4 I show that IQGAP1 is upregulated at a transcriptional level by bile acid signaling and its deletion results in increased toxin-induced liver injury and bile acid …
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Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome
… for bioassay-guided fractionation through PPARα and PPARγ activation assay. The current study relied on Panamanian flora as a source of new therapeutic agents directed toward the mitigation of metabolic abnormalities.
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A Mechanism for the Metabolic and Inflammatory Alterations Associated with Low-dose Endotoxemia
… for fatty acid metabolism, including PGC1α, PPARα, and PPARγ after very low dose LPS challenge. Further, we observe phenotypic changes in fatty acid oxidation and glucose oxidation, as well as subsequent changes in cytosolic acetyl-CoA levels and acetylation of pro-inflammatory transcription …
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The impact of erythropoietin on uraemic cardiomyopathy
… Furthermore, the protein expression of CD36 and PPARα was the same in uraemic and control hearts. At 12 weeks post-surgery, uraemic animals exhibited significantly increased collagen within the heart compared to controls, highlighting cardiac fibrosis.In summary, by 12 weeks post-induction of …
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