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Showing 1 to 17 of 17 for “"PP2"”.
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Prepositional Phrase Attachment Ambiguities in Declarative and Interrogative Contexts: Oral Reading Data
… overridden when the second prepositional phrase (PP2: <em>into her briefcase</em>) is encountered, since the <em>into</em> phrase can only be interpreted as the goal argument of the verb. Thus, PP2 necessarily supplants PP1’s initially assigned position as goal, and PP1 must be reanalyzed as a …
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Inhibition of myofibroblast contraction
… and blocked by the pharmacological agent PP2. To investigate whether blocking SMA expression alone can inhibit myofibroblast contraction, NR6 wild type fibroblasts were seeded into short cylindrical collagen-GAG matrices, and administered either media alone, media with TGF-[beta]1 …
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HIV, Antiretroviral Therapy, Pregnancy, Lactation and Bone Health in Uganda
… were collected at 36 wks gestation (PG36), 2 (PP2) and 14 wks postpartum (PP14). Dual-energy x-ray absorptiometry was used to measure bone phenotype (aBMD, bone mineral content (BMC), bone area (BA), and size-adjusted BMC (SA-BMC, adjusted for height or length, weight and BA) of the whole body …
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FROM NUCLEUS TO MITOCHONDRIA: INSIGHTS INTO THE ROLE OF TERT IN THE PROGRESSION OF PAPILLARY THYROID CARCINOMA
… Moreover, we investigated the effect of PP2, a SRC kinase inhibitor, which is supposed to inhibit the pathway that allows for TERT nuclear export, on K1 cell proliferation. We found that TERT shuttled into the cytoplasm and in some cases to the mitochondria in response to OS increase …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… Finally we found that the Lyn inhibitors PP2 and dasatinib enhanced ATRA-induced differentiation. Co-treatment with ATRA plus either inhibitor upregulated total Lyn and c-RafpS259, and increased associations between Lyn/c-Raf and cRaf/ERK. This was consistent with increased c-Raf …
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Targeting Opioid Receptor Signal Transduction to Produce Sustained Analgesia
… BAR2+/- and BAR2-/- VTA neurones. Dasatinib and PP2 (c-Src tyrosine kinase inhibitors) prevented the development of morphine tolerance in WT and MOP+/- mice and dasatinib caused its reversal in the latter. The drugs had no significant analgesic effect alone. Dasatinib did not affect morphine …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… enzyme activation, cells were pretreated with PP2 to inhibit SFK activity. We found that PP2 attenuated the NFkB and adhesion molecule pathway activated by TNFα. Depletion of dynamin-2 (Dyn2siRNA) or inhibiting GTPase activity (Dynasore) also showed reductions in ROS generation, NFkB redox …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is inhibited. PP2 abolished phosphorylation of Syk and Phospholipase Cγ−2. Fucoidan-induced platelet activation had a lag phase, which is reminiscent of platelet activation by collagen and CLEC-2 receptor agonists. Platelet …
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Gender Differences In Cardiomyocyte Remodeling and Adhesion In Response to Chronic Elevations In Myocardial Stress
… TNF-α was reversed by the Src kinase inhibitor, PP2. These results indicate that the TNF-α reduced cardiomyocyte adhesion involves Src kinases. Taken together, we conclude that TNF-α modulates myocyte adhesion and possibly accounts for the gender difference in myocyte adhesion and remodeling in …
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
… maturation. Similar effect was observed with PP2 a Src inhibitor, confirming that the effects were mediated at least in part through Src inhibition. This effect resulted in impaired osteoclast function, evidenced by reduced in vitro bone resorption. A novel in vitro coculture system comprising …
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Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
… by strain and was blocked by the Src inhibitor PP2. Finally, ILK reduction by siRNA inhibited strain-induced phosphorylation of myosin light chain and Akt. These results suggest a strain-dependent signaling pathway in which ILK association with FAK and Src mediates the subsequent downstream …
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CEACAM3: ein neuartiger phagozytischer Rezeptor der angeborenen Immunantwort zur Erkennung human-spezifischer Pathogene
… zu untersuchen. Interessanterweise inhibiert PP2 die Aufnahme der Gonokokken dosisabhängig, wohingegen die Blockade der CEACAM1- bzw. CEACAM6-vermittelten Internalisierung der Gonokokken durch Nystatin keine Auswirkungen zeigt. Auch die Proteintransduktion der dominant-negativen Version von …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… tyrosine kinase Lck also appears essential as PP2 abolished the rises. Downstream of Lck, both PI3K and PLC activation is necessary as their inhibition by LY294002 and edelfosine, respectively, abolished the rises. The rises do not involve store release via IP3 receptors and SOCE, suggesting …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… tyrosine kinase Lck also appears essential as PP2 abolished the rises. Downstream of Lck, both PI3K and PLC activation is necessary as their inhibition by LY294002 and edelfosine, respectively, abolished the rises. The rises do not involve store release via IP3 receptors and SOCE, suggesting …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… phosphatases of the PPP family such as PP1 and PP2, act specifically on serine/threonine phosphorylations; our understanding of phosphatase regulation stems from the regulation of members of the PPP family upon activation of the cAMP signalling pathway through protein kinase A. We wanted to find …
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A Study of the Genetics of Root Nodulation in Pigeonpea (Cajanus cajan) Using Indigenous Rhizobia
… rhizobial strains, namely, (Rhizobium sp.; 33a-PP2) and (Rhizobium multihospitium; 37a-PP4) were identified as ideal for RDW and SDW, respectively. The biplot analysis also revealed that for SDW, E1 (Bambara groundnut) and E4 (pigeonpea), in that sequence, were plotted closet to the epicentre. …