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Showing 1 to 20 of 30 for “"POPC"”.
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Simulações computacionais do peptídeo híbrido Plantaricina-Pediocina em membranas fosfolipídicas puras e binárias compostas por POPC: POPG
… interagindo com membranas puras e mistas de POPC e POPG utilizando os parâmetros do campo de força GROMOS 53A6 e 54A7. As simulações com uma unidade do peptídeo revelaram a atualização 54A7 era a mais adequado para modelagem desses sistemas. Os mapas de estrutura secundária mostraram que o …
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Theoretical and computational modeling of peptide-lipid bilayer interaction studied by dynamic force spectroscopy
… (SecA2-11) interacting with both zwitterionic POPC lipid and polar E. Coli membranes. Furthermore, molecular dynamics (MD) simulations are used to explored the conformational dynamics of SecA2-11 during its interaction with both POPC and anionic POPG lipid bilayers. (3) Finally, MD simulations …
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A Molecular Dynamics Study on the Interaction of Tea Catechins and Theaflavins with Biological Membranes
… in lipid bilayer systems which are both pure (POPC) and representative of HepG2 cancer cells (POPC and POPE). Our simulations show that the catechins and theaflavins evaluated have a strong affinity for the lipid bilayer \textit{via} hydrogen bonding to the bilayer surface, with many of the …
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Patterns of acute kidney injury and functional outcome scores in pediatric patients hospitalized with acute respiratory failure
… and Pediatric Overall Performance Category (POPC) scores from pre-PICU baseline and PICU discharge were compared. New substantive morbidity was defined as an increase in PCPC or POPC by ≥1 point. Results The final analysis included 324 patients. Severe AKI was present in 19.7% of patients. …
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Liposome drug delivery systems for anticancer agents
… formulation of the peptide comprising POPE/POPC/cholesterol/C16 mPEG 2000 ceramide (20.8:31.2:40:8, mol%) was thereby developed with a peptide-encapsulation efficiency of 47.8%. The liposomal cyclic peptide exhibited dose-dependent toxicity to MCF7 human breast cancer cells and stability …
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Structural and functional studies of the C-terminal domain of human apolipoprotein A-I: Limited proteolysis and deletion mutagenesis
… (DPPC) or palmitoyloleoyl PC (POPC) by chymotrypsin, trypsin, elastase, or subtilisin generated a major fragment of $\sim$22 kDa. Under milder conditions proteolysis of lipid-free apoA-I produced a fragment of similar size. The fragments shared the same N-terminus as intact …
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Water-Soluble Deep-Cavity Cavitands: Synthesis, Molecular Recognition, and Interactions with Phospholipid Membranes
… for their ability to permeabilize liposomal POPC membranes. One host showed very high potency in permeabilizing membranes, while three other hosts showed moderate activity. Host binding of POPC was found to be at least one factor in host-induced permeabilization. A requenching assay to …
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Solid-state NMR spectroscopy applied to model membranes: effects of polyunsaturated fatty acids
… or 1-palmitoyl-2-oleoylphosphatidylcholine (POPC), as a monounsaturated control, and cholesterol (chol) (1:1:1 mol) in a model membrane was examined by solid state 2H NMR spectroscopy. Solid state 2H NMR spectroscopy extracts details of molecular orientation and anisotropy of molecular …
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Theory of the general orientation dependence of ²H NMR spin-lattice relaxation and experiments on model membranes
… 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). The order parameter S20 (=SCD), was determined, model-independently, to be negative. The rotational diffusion model as formulated by Schindler and Seelig (Biochem.14:2283) is incorrect based on the range of experimentally acceptable S40. The …
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Rate dependent rupture of solid-supported phospholipid bilayers.
… 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) solid-supported lipid bilayers were created on mica using vesicle fusion technique and then ruptured normal to the surface using a silicon nitride cantilever tip (radius#80nm). High resolution force spectroscopy was performed using the …
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Role of the Lipid Environment and Cholesterol Content in the Function of CFTR Modulators
… of four common membrane mimetics: SDS, LDAO, POPC, and POPC + varying cholesterol concentrations. Then, we evaluated the effects of two CFTR modulators - Ivacaftor and Lumacaftor (and their combination, Orkambi) - on the folding of mutant CFTR hairpins, with a focus on whether these drugs can …
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SILOXANE-CONTAINING PHOSPHOLIPIDS AS POTENTIAL DRUG DELIVERY SYSTEMS
… 1-palmitoyl-2-oleoyl-sn-glycero-3-phospcocholine (POPC) and controlled released when using the model compound, calcein. With the siloxane-phospholipids being studied, zero-order release was observed and in some instances appeared to be independent of the pH of the release media.
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Interaction of sPLA2 phospholipases with assemblies of natural and synthetic amphiphiles and the development of a drug delivery system for the treatment of breast cancer
… dye, bromothymol blue (BTB), in which different POPC self-assemblies (liposomes or mixed micelles with Triton X-100) were used to assess the enzyme activity. We used this assay to perform a comparative analysis of PLA2 kinetics on these supramolecular assemblies, and we determined the kinetic …
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Mechanism Determination of the Effects of Pancratistatin on Model Mitochondrial Membranes
… glycero-3-phosphocholine (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), and tetraoleoyl cardiolipin (TOCL). Small-angle neutron and X-ray scattering (SANS and SAXS) were utilized to determine how PST influences membranes structure. Molecular dynamics …
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Protein Dynamics: Studies of Adenylate Kinase Mutants From Escherichia Coli and Characterization of Adenylate Kinase Isoforms From Murine Cells. Applications of Fluorescence Spectroscopy and Microscopy
… showed no binding affinity to GUVs made from POPC in the fluorescence imaging study. However, when AK1beta was co-expressed with N-myristoyl-transferase (NMT), an enzyme that can myristoylate proteins with the proper signal in E. coli, the purified protein named as AK1betamyr showed binding …
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MODULATION AND INTERACTIONS OF CHARGED BIOMIMETIC MEMBRANES WITH BIVALENT IONS
… free energy of the lipid systems PtdIns(4, 5)P2 -POPC, PtdIns(4, 5)P2, and POPC as they are modulated by bivalent ions. In the fourth part, I report on my foray in engineering a light-based system that relies on different dye properties to simulate calcium induced calcium release (CICR) that …
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Towards atomistic characterization of blood coagulation proteins by NMR spectroscopy
… into both phospholipid Nanodiscs and POPC/DPPC liposomes. The impact of different lipid preparations on the structure of TF as well as mTF functional assay data are presented. Our preliminary results indicate that TF retains its primarily beta-sheet secondary structure upon membrane …
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A thermodynamic study of the effects of membrane composition on the binding affinity of annexin a5.
… and acidic phospholipid mixtures ((60:40) (POPC:POPS)) relative to solution state (without membrane) calcium ion binding. We hypothesize that the shift to higher affinity calcium ion binding is modulated by the composition of the membrane. We tested this hypothesis by introducing …
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Effect of repurposed drugs on the cellular properties of childhood cancer: in vitro & in silico studies
… 1-Palmitoyl-2-oleoylphosphatidylcholine (POPC), palmitoylsphingomyelin (PSM) and cholesterol (CHOL) with different compositions. Results of the experimental MTT assays showed that while both loratadine and carvacrol are cytotoxic against the A204 cells, loratadine produced the greater …
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A single AKH neuropeptide activating three different fly AKH-receptors: an insecticide study via computational methods
… Under molecular dynamics simulation, in a POPC membrane, the β-2AR receptor-like complexes transformed to rhodopsin-like. The identification and characterisation of the ligand-binding site of each receptor provide novel information on ligand-receptor interactions, which could lead to the …
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