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Showing 1 to 3 of 3 for “"POLQ"”.
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Dna Polymerase Θ (Polq) and The Cellular Defense Against Dna Damage
<p>In mammalian cells, DNA polymerase θ (POLQ)<strong> </strong>is an unusual specialized DNA polymerase whose <em>in vivo</em> function is under active investigation. The protein is comprised of an N-terminal helicase-like domain, a C-terminal DNA polymerase domain, and a large central domain that …
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UNRAVELING THE MOLECULAR MECHANISM OF BRCA2-POLTETA INTERPLAY IN PREVENTING SSDNA GAP ACCUMULATION DURING DNA REPLICATION
DNA Polymerase theta (POLθ), encoded by POLQ, plays a critical role in alternative non-homologous end joining (alt-NHEJ), a backup pathway for repairing DNA double-strand breaks in the absence of homologous recombination. The synthetic lethal relationship between POLQ and BRCA1/2 has been …
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Quantitative modelling of CRISPR-Cas editing outcomes
… than controls. I highlight Nbn, Lig4 and PolQ as examples of knockouts with consistent effects on certain mutation types. I examine how the known sequence-determinants of Cas9 outcomes affect outcome preference knockout lines. Lastly, I use this understanding to train models that predict …