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Showing 1 to 1 of 1 for “"POL theta"”.
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UNRAVELING THE MOLECULAR MECHANISM OF BRCA2-POLTETA INTERPLAY IN PREVENTING SSDNA GAP ACCUMULATION DURING DNA REPLICATION
DNA Polymerase theta (POLθ), encoded by POLQ, plays a critical role in alternative non-homologous end joining (alt-NHEJ), a backup pathway for repairing DNA double-strand breaks in the absence of homologous recombination. The synthetic lethal relationship between POLQ and BRCA1/2 has been …