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Showing 1 to 1 of 1 for “"PNS dilation"”.
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Dilations of the Endoplasmic Reticulum Contribute to Spongiform Degeneration and Unlock a Door to a Unified Model of Neuropathological Features in Prion Diseases
… protein response (UPR), cause profound ER dilation, particularly in the perinuclear space (PNS). Our pharmacological and genetic experiments implicate the transient receptor potential vanilloid 2 (TRPV2) calcium leak channel in this vacuolation process. Finally, we demonstrated that ER …