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Showing 1 to 3 of 3 for “"PNA FISH"”.
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Variation in chromosomal aberration induction in differing ATM and ASPM genotypic backgrounds detected via a modified PNA FISH technique
A modified PNA (peptide nucleic acid) FISH (fluorescence in situ hybridization) method has been developed for efficient quantitative and qualitative analysis of chromosomal aberration formation. PNA FISH was used to detect a heightened sensitivity in mouse fibroblasts in response to ionizing …
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Human embryonic stem cells for genotoxicity testing
… genotoxicity testing. Chromosomal analysis by PNA-FISH and mFISH following Mitomycin C treatment revealed that hESCs are significantly more resistant to genotoxic damage than normal human fibroblast cell line as evidenced by the lower levels of chromosomal aberration in hESCs. The resistance of …
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Utilization of fish for constitutional and acquired chromosomal abnormalities for diagnostic and prognostic purposes
ABSTRACT Utilization of FISH for Constitutional and Acquired Chromosomal Abnormalities for Diagnostic and Prognostic Purposes Amy L. Shackelford Fluorescence in-situ hybridization (FISH) is a useful molecular cytogenetics technique for counting chromosomes and identifying specific chromosomal …