Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"PMK-1"”.
-
Genetic analysis of innate immunity in Caenorhabditis elegans
… Several conserved activators in the p38 PMK-1 pathway have been identified and are required for pathogen resistance to the bacterium Pseudomonas aeroginosa. Thus far, screens have been performed to identify mutants that are susceptible to pathogen infection. Here, I will discuss a mek-1 …
-
Genetic analysis of p38 mitogen-activated protein kinase signaling in innate immunity and stress physiology of Caenorhabditis elegans
… as the key transcriptional regulator of the PMK- 1 p38 MAPK-dependent immune response to pathogens. These data suggest a model in which the PMK- 1 p3 8 MAPK phosphorylates ATF-7 and switches it from a transcriptional repressor to a transcriptional activator of effector genes of the innate …
-
Neuronal Regulation of the Innate Immune Response in Caenorhabditis elegans
… receptor, DOP-4, which suppresses the conserved PMK-1/p38 immune pathway in C. elegans. We also demonstrated that the manipulation of a dopaminergic neural circuit can alter the immune response upon pathogen infection. Previous studies showed that an octopamine receptor, OCTR-1, functions in …
-
Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity
… expression of XBP-1 is sufficient to overcome PMK-1 dependent larval lethality on a lawn of pathogenic Pseudomonas aeruginosa. Further, we demonstrate that XBP-1 deficiency results in constitutive ER stress even in the absence of pathogenic infection. This elevated ER stress is reflected by …
-
Regulation of the Ras Signaling Network in C. Elegans Development
… GCK-2, a CNH domain-containing MAP4 Kinase, and PMK-1/p38 MAP kinase to promote 2˚ fate. We also show that RGL-1 plays opposing and genetically separable roles in VPC fate patterning. RGL-1 promotes 2˚ fate via canonical GEF-dependent activation of RAL-1 and 1˚ fate via a non-canonical …