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Showing 1 to 9 of 9 for “"PMCA4"”.
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Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… Plasma Membrane Calcium ATPase 4 (PMCA4) belongs to a family of transmembrane ion transporters that extrude calcium from the cytosol to the extracellular environment (Strehler, 2015). They are the only high-affinity Ca2+ extrusion system in mammalian cells encoded by the ATP2B1-4 …
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Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… role for the Plasma Membrane Calcium ATPase 4 (PMCA4) protein in endothelial cells, acting via inhibition of the pro-angiogenic calcineurin/NFAT signalling pathway. However, we hypothesise that other intracellular pathways might be regulated by PMCA4 in endothelial cells during VEGF stimulation …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… like Plasma Membrane Calcium ATPase 4 (PMCA4) may play an important regulatory role. PMCA4, encoded by ATP2B4, maintains calcium homeostasis and modulates signalling pathways through its scaffolding function at the plasma membrane. This study investigates the contribution of PMCA4 to …
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Role of the Plasma Membrane Calcium ATPase as a Negative Regulator of Angiogenesis
… removal function of the pump. Interestingly, PMCA4 has been shown to interact with calcineurin in endothelial cells. The aim of our study was to further our understanding of PMCA4s regulation of the calcineurin/NFAT pathway specifically in endothelial cells and establish if PMCA4 has a role in …
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A NOVEL SELECTIVE INHIBITOR FOR PLASMA MEMBRANE CALCIUM ATPase 4 IMPROVES VEGF-MEDIATED ANGIOGENESIS
… role for the plasma membrane calcium ATPase 4 (PMCA4) protein as a negative regulator of VEGF-induced angiogenesis via interaction with calcineurin. The recent identification of aurintricarboxylic acid (ATA) as a selective inhibitor of PMCA4 prompted us to hypothesise that inhibition of PMCA4 …
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Molecular and cellular mechanisms implicated in the regulation of cellular PMCA expression during pulmonary arterial hypertension
… dose dependent reduction (~ 40-50% reduction) of PMCA4 in human pulmonary artery endothelial cells at the mRNA and protein level. Further data obtained equally show that the silencing of PMCA4 in pulmonary artery endothelial cells (PAEC) sensitized PAEC to TNF-α induced apoptosis; approximately …
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Investigating the expression of plasma membrane calcium ATPase (PMCA) in patient-derived glioblastoma cultures
… a specific focus on isoforms PMCA1, PMCA2, and PMCA4. Patient-derived glioblastoma cultures and biopsy samples were employed to investigate PMCA expression patterns at both the transcript and protein levels. Quantitative RT-PCR and western blotting revealed that PMCA1 and PMCA4 were …
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TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… (STIM1) inhibits plasma membrane Ca2+/ATPase 4 (PMCA4) function during T cell activation resulting in sustained elevation of Ca2+ signals(Ritchie, Samakai, & Soboloff, 2012). This interaction requires upregulation of both STIM1 and PMCA4. In this thesis, I hypothesize that changes in Ca2+ signals …
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PMCA as a regulator of calcium/calmodulin-dependent signal transduction pathways
… signal transduction pathways. PMCA4 has already been shown to inhibit the NFAT family of transcription factors by its interaction with calcineurin A in mammalian cells when ectopically expressed. This prompted the investigation into other isoforms of PMCA that may interact with …