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Showing 1 to 20 of 71 for “"PLP"”.
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Speech recognition by clustering wavelet and PLP coefficients
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
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Subcellular labelling of myelin protein (PLP and DM20) in the central nervous system
The Plp1 gene encodes the two proteins DM20 and PLP. Ultrastructural techniques will provide the best resolution to establish the sub-cellular localisation of the two myelin protein isoforms encoded by the Plp1 gene in mice and thus provide insight into the functions for the two isoforms. The gene …
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PLP-Dependent α-Oxoamine Synthases: Phylogenetic Analysis, Structural Plasticity, and Structure-Function Studies on 5-Aminolevulinate Synthase
… synthase family of pyridoxal 5'-phosphate (PLP)-dependent enzymes. The evolutionary relationships among α-oxoamine synthases representing a broad taxonomic and phylogenetic spectrum have been examined to help identify residues that may regulate substrate specificity. The structural …
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Developing an in-depth understanding of the prevalence, risk factors and treatment recommendations for phantom limb pain, and patient-generated care priorities for people who have undergone lower limb amputations
… than placebo for reducing Phantom Limb Pain (PLP). Moreover, there is evidence suggesting that people with amputations may not be getting the treatment they want at different time-points after amputation. In consideration of these points, a research project comprised of a series of …
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Function and Pain in Community-Dwelling, Adult Mid-Southerners with Limb Loss
… pain assessment of Phantom limb pain (PLP), Residual limb pain (RLP), and Other Pain (OP). Pain intensity was assessed with a 5 point verbal descriptor scale converted to a numeric scale of 0-4.</p> <p><strong>Results:</strong> The mean SIP68 was 19.7 (range 1-54) and the mean LLIP12 …
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The Engineering and Development of pH-Responsive Biopolymers for Drug Delivery Applications
… biocompatible poly (L-lysine iso-phthalamide) (PLP) polymer and its derivatives. Poly (L-lysine isophalamide) is a unique polymer that contains pendant carboxylate group and modification with phenylalanine was able to enhance the intracellular delivery efficiency of the polymer. However, the …
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Proteomic Approaches For Profiling Cofactor-Dependent Proteins In Mycobacterium Tuberculosis
… Chapter 1 provides a broad overview of PLP-dependent enzymes in Mycobacterium tuberculosis, the causative pathogen of tuberculosis. PLP-dependent enzymes represent an important class of highly “druggable” enzymes that perform a wide array of critical reactions to support all organisms. …
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The effectiveness of graded motor imagery for reducing phantom limb pain and disability in amputees
Introduction Phantom limb pain (PLP) is described as painful sensations felt in the missing portion of an amputated limb. PLP occurs in up to 85% of amputees, making it the most common painful condition secondary to amputation. PLP interferes with sleep, mobility, and work, general activities of …
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Dietary vitamin B6 supplementation promotes the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague Dawley rats
… in increased fibrosarcoma pyridoxal phosphate (PLP) concentrations and a significant inverse relationship between tumor PLP concentration and tumor volume in mice. This suggests that, in contrast to data reported for normal cells, tumor cells are capable of accumulating supplemental B6. In the …
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Analyse transgener Mauslinien mit zelltypspezifischer Expression fluoreszenter Proteine als Modelle für akute Hirntraumata
… Protein DsRed unter der Kontrolle des PLP-Promotors exprimiert wurde, charakterisiert. Beide Linien zeigten ein in jeder Hinsicht ähnliches Expressionsmuster. DsRed wurde vom zweiten Postnataltag an im Hirnstamm exprimiert. Es fand sich in diesen beiden Linien nur Expression in Zellen, …
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Separation and quantitation of the seven forms of vitamin B-6 in plasma and 4-pyridoxic acid in urine of adolescent girls by reverse phase high performance liquid chromatography
… plasma B-6 vitamer [pyridoxal phosphate (PLP), pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), pyridoxal (PL), pyridoxine (PN), and pyridoxamine (PM)] and 4-pyridoxic acid (4-PA) concentrations and urinary 4-PA levels of 28 white adolescent females, 12-15 years, having …
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The roles of papain-like protease-related proteins in viral replication and host immunity
Viral papain-like proteases (PLPs)-related proteins have been shown to be actively involved in host innate immunity manipulation and virus replication. In this dissertation, the research were focused on the elucidation of biological roles of nidoviral PLPs-related proteins in innate immunity …
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Transgenic complementation of rumpshaker with wild type proteolipid protein
… the x-linked myelin proteolipid protein 1 gene (PLP1) cause the heterogeneous syndromes of Pelizaeus Merzbacher disease (PMD) and Spastic paraplegia type 2(SPG2) in man (Hudson et al., 2004). A single base change mutation in our spontaneous mouse model rumpshaker (Plpjp-rsh)(Ile186Thr) (Schneider …
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Some Aspects of the Biochemistry of Malabsorption from the Upper Intestinal Tract
… B6, in the form of pyridoxal-5'-phosphate (PLP), is convenient to use but further mechanisation is necessary to improve reproducibility. 182 gastrointestinal patients and 124 normals have had their serum PLP measured. Amongst normals, women had a statistically significant lower mean serum …
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The effects of increased Plp1 gene dosage on expression and processing of myelin proteins
Mutations in proteolipid protein 1 (PLP1), an X-linked gene causes Pelizaeus-Merzbacher disease (PMD) in humans. The most frequent cause of PMD is the duplication of PLP1, which encodes the major myelin membrane protein of the human CNS. The #66 transgenic mice with extra copies of the wild type …
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POLSYS_PLP: A Partitioned Linear Product Homotopy Code for Solving Polynomial Systems of Equations
… behind and performance of the new code POLSYS_PLP, which consists of Fortran 90 modules for finding all isolated solutions of a complex coefficient polynomial system of equations by a probability-one homotopy method. The package is intended to be used in conjunction with HOMPACK90, and makes …
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Biochemical Studies of Aromatic Amino Acid Decarboxylases and Acetaldehyde Synthases
Pyridoxal 5'-phosphate (PLP)-dependent enzymes widely exist in most living organisms from bacteria to human. Among different types of PLP-dependent enzymes, aromatic amino acid decarboxylases play critical physiological roles because many aromatic amines are essential neurotransmitters. This …
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Mechanisms of Multivesicular Body Biogenesis and Exosome Release
… wurde der Transport von Proteolipidprotein (PLP) in Oli-neu Zellen, einer Zelllinie von Oligodendrozytenvorläuferzellen untersucht. Es konnte gezeigt werden, dass PLP in eigene Subdomänen der Endosomenmembran tranportiert wird. Der Transport von PLP ins Lumen der Endosomen ist dabei nicht …
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Synthesis and applications of aminated biopolymers
… of pyridoxal and pyridoxal 5'-phosphate (PLP) for application in non-enzymatic deamination of L-phenylalanine to phenylpyruvate. An ionic complex between PLP and Q188 was formed and successfully utilised to convert L- phenylalanine into phenylpyruvate, however, the polymer complex showed a …
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Mechanistic studies of rabbit muscle glycogen phosphorylase
… contains a molecule of pyridoxal phosphate (PLP), of which the phosphate moiety is essential for catalysis. To investigate the role of the cofactor phosphate moiety two phosphonate analogues of PLP, 5'-deoxypyridoxal-5'-methylenephosphonic acid (9) and5'-deoxypyridoxal-5'-difluoromethylene …
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