NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 21 for “"PLGA nanoparticles"”.

  1. Development of versatile drug delivery strategies using PLGA nanoparticles

    Fay, FrancoisQueen's University Belfast2010

    … to improve efficacy. Development of polymeric nanoparticles (NP) with slow drug-release kinetics coated with targeting ligands enables cell-specific sustained drug delivery, whilst minimising off-target side effects. In this thesis, a range of novel poly(lactic-co- glycolic acid) (PLGA) NP …

    qu-belfast Repository record

  2. Consistent Fabrication of Ultrasmall PLGA Nanoparticles and their Potential Biomedical Applications

    Lohneis, Taylor PaigeVirginia Tech2019

    … the last few decades. Specifically, ultrasmall nanoparticles, ranging in size from 5 to 50 nm, are highly sought after for their physical and chemical properties and their ability to be easily transmitted though the bloodstream. By adjusting the material properties, size, surface potential, …

    vt Repository record

  3. INVESTIGATION OF LIGAND SIZE ON TARGETED PLGA NANOPARTICLES FOR HER2 BREAST CANCER: TRASTUZUMAB AND ITS ScFv ANTI-HER2 ANTIBODY

    Zagzoog, Ayat H 1990-University of Saskatchewan2018

    … breast cancer. Poly (D, L-lactide-co-glycolide) (PLGA) polymer, which is approved by FDA, was used to form nanoparticles (NPs) encapsulating docetaxel (DOC) as chemotherapy. HER2 antibody moieties, either whole IgG (TrAb) or single chain fragment variable (ScFv), were decorated on the PLGA NPs …

    sask Repository record

  4. Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications

    Sun, Yu, author, Li, Yan Vivian, advisor, Bailey, Travis, committee member, Wang, Zhijie, committee memberColorado State University. Libraries2019

    … have been dramatically improved. The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention …

    colostate Repository record

  5. Multifunctional Nanoparticles for Cancer Therapy

    Chandratre, Shantanu S.Creighton University2014

    … present study was to develop and characterize nanoparticles containing two anticancer agents having different mechanisms of action that would target both differentiated as well as cancer stem cells. The two hydrophobic antitumor agents (cyclopamine and paclitaxel) were entrapped in glyceryl …

    creighton Repository record

  6. Development and characterization of advanced nitric oxide-delivering polymeric systems against cardiovascular complications

    Acharya, GayathriUniversity of Missouri--Kansas City2013

    … incorporated with poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing DETA NONOate were formulated for the prevention of valve complications. Similarly, S-nitrosoglutathione incorporated polycaprolactone (PCL) matrix system was developed for combating in-stent restenosis. PLLA matrices …

    umkc Repository record

  7. Development of SiRNA Incorporated Surface Modified Polymeric Nanoparticle for the Potential Treatment of Global Cerebral Ischemia

    Poojary, SannidhiCreighton University2025

    … issue and suppress BRD4, this study developed PLGA nanoparticles coated with Polysorbate-80 (PS-80) and Polyethylene glycol (PEG) to incorporate siRNA and effectively deliver across the BBB. The study engineered siRNA-incorporated PLGA nanoparticles with PS-80 and PEG coating via a modified …

    creighton Repository record

  8. Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis

    Mahadevan, Reena2013

    Nanoparticles are emerging as versatile vehicles for drug delivery, providing targeting, protection, and controlled-release capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) (PLGA) are biodegradable, exhibit tunable drug release, and have encapsulated …

    washington Repository record

  9. Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes

    Abudalo, RawanQueen's University Belfast2020

    … we employed poly (lactic-co-glycolic acid) (PLGA) nanoparticles for preferential targeting of liraglutide and exendin-4 to inflammatory cells. Whilst liraglutide-PLGA nanoparticles displayed equivalent GLP-1R binding and activation to native liraglutide in U2OS cells and CHL cells, …

    qu-belfast Repository record

  10. Development and Characterization of Controlled Drug Delivery Using Nanoparticles

    Chen, Li

    … biodegradable Poly (DL-lactideco- glycolide) (PLGA) nanoparticles by simple nanoprecipitation method. The small size of these particles (<200nm) could be beneficial to realize passive tumor-targeted drug delivery through enhanced permeability and retention (EPR) effects. These drug-containing …

    uno Repository record

  11. Polyelectrolyte multilayers for tunable release of antibiotics and other therapeutics

    Chuang, Helen FMassachusetts Institute of Technology2008

    … incorporation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating gentamicin, [7] evaluation of film sterilizability via FDA-approved methods, and [8] design and characterization of a multi-drug coating for orthopedic implants for dual antimicrobial and tissue regenerative actions.

    mit Repository record

  12. Synthesis and Characterization of Multi-Functional Nanoparticles for Therapeutic and Biosensing Applications

    Baynes, CaylaThe University of Arizona.2018

    … of poly(DL-lactic acid-co-glycolic acid) (PLGA) or poly(ethylene glycol)-PLGA and stabilized by polyvinyl alcohol (PVA) or Pluronic F-68 for the encapsulation of an insulin derivative, a model therapeutic enzyme, and anticancer drugs. The protein hormone release from biodegradable …

    arizona-thes Repository record

  13. Nanoparticle-Based Drug Delivery and the Impacts on Cancer Cell Biophysical Markers

    Babahosseini, HesamVirginia Tech2015

    … delivery using Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with SphKIs versus conventional delivery. Cells treated with SphKIs showed significantly higher impedance magnitudes at all four frequencies. The bioelectrical parameters extracted using a model also revealed that …

    vt Repository record

  14. Combination of STING and TLR 7/8 agonists as vaccine adjuvants for cancer immunotherapy

    Shah, Manan Chandraj2021

    … agonists, individually or in combination. Also, PLGA nanoparticles were formulated and characterized in vitro. We observed that the combined treatment showed enhanced DC activation and M2 repolarization compared to the individual agonists. However, we also observed an increased induction of …

    umn Repository record

  15. Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection

    Gokulgandhi, Mitan R.University of Missouri--Kansas City2013

    … virus strains. Furthermore, prodrug loaded PLGA nanoparticle formulations were prepared and characterized. Overall, improvement in physicochemical properties, lipophilicity, interaction with SMVT transporter, higher tissue-buffer partition coefficient and rapid conversion into parent …

    umkc Repository record

  16. Antioxidant Nanoparticles as Delivery Systems

    Astete R., Carlos ErnestoEngineering Science (Interdepartmental Program)2017

    … the study was to develop antioxidant polymeric nanoparticles as a new delivery system for food and pharmaceutical applications. Natural antioxidants like alpha-tocopherol, vitamin C, and carnosine, are responsible to protect biological systems against free radicals attack. The conjugation of …

    lsu-thes Repository record

  17. Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury

    Gagan, Joshuah Marian2025

    … incorporated into poly-lactic-co-glycolic-acid (PLGA) nanoparticles (NPs), a vehicle chosen for its desired properties suitable for inhalational delivery. Klotho-containing PLGA NPs were characterized for inhalational delivery and screened in A549 cells exposed to cigarette smoke. WT or …

    utswmed Repository record

  18. Engineering Materials for Non-Compressible Torso Hemorrhage and Internal Bleeding

    Hong, Celestine Jia HueyMassachusetts Institute of Technology2022

    … size on their interactions with platelets. Small nanoparticles were observed to result in an increased percentage of specifically-bound single platelets under flow and intermediate nanoparticles were observed to result in the greatest degree of platelet recruitment to a platelet-collagen surface. …

    mit Repository record

  19. Tools for decoding the structure-function relationships of biopolymers in nanotechnology and glycobiology

    Soundararajan, VenkataramananMassachusetts Institute of Technology2010

    … dexamethasone from poly lactic-co-glycolic acid (PLGA) nanoparticles is precisely predicted. The Voxel platform emerges as a powerful and versatile tool for deducing the dynamics in interplay of polymer, drug, and water molecules, thus permitting the rational design of optimal nanotechnology …

    mit Repository record

  20. Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis

    Yang, XiaoyanUniversity of Missouri--Kansas City2015

    … this project is to develop drug-loaded polymeric nanoparticles suspended in a biocompatible gel for topical delivery of therapeutic agents commonly employed in the treatment of ocular viral/bacterial keratitis. PART 1: Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) of dipeptide …

    umkc Repository record

Page 1 of 2