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Showing 1 to 6 of 6 for “"PLGA microspheres"”.
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Elucidation of Drug Release Mechanisms in PLGA Microspheres
… elucidate mechanisms of drug release in PLGA microspheres. We showed the effect of microsphere size and presence of an antacid on the stability and release of plasmid DNA from PLGA microspheres. We demonstrated that the use of Mg(OH)2 as a stabilizing excipient affected the surface …
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Investigation of properties affecting controlled release of macromolecules from PLGA microspheres
Poly(lactide-co-glycolide), or PLGA, microspheres offer a widely-studied biodegradable option for controlled release of therapeutics. An array of fabrication methodologies have been developed to produce these microspheres with the capacity to encapsulate therapeutics of various types; and produce …
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Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
… during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) as well as stability during freeze-drying or/and nebulization (NEED%), were evaluated …
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Stability of proteins within biodegradable microspheres
… In particular, poly(lactic-co-glycolic acid) (PLGA) microspheres have been extensively studied for controlled-release protein delivery. However, significant issues arise in formulating such delivery systems since few proteins have been successfully encapsulated and released from these …
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A Novel Biostable 3D Porous Collagen Scaffold for Implantable Biosensor
… drug)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres/porous collagen scaffold composite for implantable glucose sensors. The composite system showed a much slower and sustained drug release than the standard microspheres. The composite system was also shown to not significantly …
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Modeling of controlled-release drug delivery from autocatalytically degrading polymer microspheres
… is developed for the simultaneous treatment of PLGA degradation and erosion and diffusive drug release with autocatalytic effects and nonconstant effective diffusivity of the drug. A mechanistic reaction-diffusion model with pore evolution coupled to hydrolysis and related to the effective …