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Showing 1 to 8 of 8 for “"PLGA Polymer"”.
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Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application
… potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable polymers used are poly(L-lactic acid) …
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A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery
<p>Poly lactide‑co‑glycolide (PLGA) polymer has been the polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic …
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Synthesis and Characterization of Injectable Star-shaped Poly(Lactide-co-Glycolide-co-Acrylate) Macromers
<p>Polymers, as hydrogel macromers, have been studied and widely applied to develop scaffolds in tissue engineering since 1990s, because they offer a number of advantages over other materials such as the ability to tailor mechanical properties and degradation kinetics based on various applications. …
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Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… of this project is to develop drug-loaded polymeric nanoparticles suspended in a biocompatible gel for topical delivery of therapeutic agents commonly employed in the treatment of ocular viral/bacterial keratitis. PART 1: Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) of …
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Synthesis, characterization and applications of peptide-coated nanoparticles
… potent drugs. Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful biodegradable polymers used in NPs formulations, mainly due to its biocompatibility and biodegradability. Polyethylene glycol (PEG) is one of the most commonly used moieties to prolong the NPs stability in serum. …
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Interaction of sPLA2 phospholipases with assemblies of natural and synthetic amphiphiles and the development of a drug delivery system for the treatment of breast cancer
… interaction of PLA2 with bilayer vesicles (lipid/polymer-based) and we found that this interaction varies depending on the distribution of PEG corona on the bilayer surface. Within this framework, we have investigated the action of phospholipases PLA1 and PLA2 towards destabilizing liposomes made …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
… was conjugated to poly (lactide) co-(glycolide) (PLGA) polymer by disulfide bonds, (HA-ss-PLGA). HA is a natural ligand for CD44 receptors overexpressed on breast cancer cells. Disulfide bonds undergo rapid reduction in the presence of glutathione, present in breast cancer cells. The mixed …
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INVESTIGATION OF LIGAND SIZE ON TARGETED PLGA NANOPARTICLES FOR HER2 BREAST CANCER: TRASTUZUMAB AND ITS ScFv ANTI-HER2 ANTIBODY
… breast cancer. Poly (D, L-lactide-co-glycolide) (PLGA) polymer, which is approved by FDA, was used to form nanoparticles (NPs) encapsulating docetaxel (DOC) as chemotherapy. HER2 antibody moieties, either whole IgG (TrAb) or single chain fragment variable (ScFv), were decorated on the PLGA NPs …