Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"PLEKHS1"”.
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DISSECTING THE FUNCTION AND INTERACTOME OF PLEKHS1 IN PROSTATE TUMORIGENESIS
… Using this methodology, we have found that PLEKHS1 was specifically recovered with Class IA PI3Ks and that association was dramatically increased in Pten -/- prostate. To further investigate the function and interactions of PLEKHS1 in vivo, we generated two mouse models: a Plekhs1-null line …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… PI3K activation in healthy mouse prostate, and PLEKHS1 as the primary driver of oncogenic PI3K activation in cancerous, PTEN-null mouse prostate. PTEN phosphatase is a tumour-suppressor and inactivated commonly in prostate cancers. PLEKHS1 is otherwise a poorly characterised protein. This thesis …