Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"PLCG2"”.
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Modeling of NK Cells in Pediatric Patients With Unusually Severe or Recurrent HSV Using High-Dimensional Flow Cytometry
… and defects in NK cytolytic function. <em>PLCG2</em> haploinsufficient variants found in 2 HSV patients causing PLCγ2 hypophosphorylation, and loss of cytolytic function in NK cells is a novel finding recently published by Alinger et al from our lab in 2023. Prior to that study, …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… a small fraction, whereas <em>BTK</em> and <em>PLCG2</em> mutations are abundantly retained at VEN relapse. By single-cell RNA sequencing, VEN relapsed CLL distributed into 5 clusters. Broadly, CLL cells downregulated <em>BCL2 </em>and gained BCL-XL/<em>BCL2L1</em> and BIM/<em>BCL2L11 </em>at …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… a specific role of the phospholipase C G2 (PLCG2) enzyme. PLCG2-dependent Ca2+ release at NCE sites occurs through the activation of the inositol trisphosphate receptor (IP3R) on the ER membrane and is required for the fission of EGFR/CD147-positive NCE vesicles from the PM. At the …
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Investigation of the ABI3 protein in microglia and its association with Alzheimer’s disease in TgCRND8 mouse model
… A cluster of these genes, including TREM2, PLCG2 and ABI3, are highly expressed in microglia and their exact function in these cells is poorly understood. Since microglial dysfunction is thought to play an important role in AD pathogenesis, this thesis was aimed at analysing the expression …
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The novel phosphorylation site PLCγ2 Y1217 facilitates the TREM2 amyloid-β sensing pathway in microglia
… within microglia and include *BIN1*, *TREM2*, *PLCG2* and *CLU*. The TREM2 R47H mutation carries the second highest genetic risk factor for LOAD and one allele increases risk of AD three-fold. TREM2 is an immunoreceptor expressed on microglia and detects anionic damage associated molecular …
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The role of BCAP in regulating the TLR signalling pathway
Toll-like receptors (TLRs) are crucial sensors in innate immunity against microbial infections. Their pro-inflammatory signal transduction typically involves the oligomerisation of downstream TIR-domain-containing adaptors MAL and MYD88. BCAP (B-cell adapter for PI3K) was identified as a negative …