Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"PLCγ2"”.
-
The novel phosphorylation site PLCγ2 Y1217 facilitates the TREM2 amyloid-β sensing pathway in microglia
… downstream responses, such as phosphorylation of PLCγ2 and intracellular calcium release. PLCγ2 was shown to be phosphorylated at tyrosine 1217, not the canonical residues Y753 or Y759 as they are in the B cell receptor signalling pathway, in response to oligomeric Aβ. Additionally, I found that …
-
Modeling of NK Cells in Pediatric Patients With Unusually Severe or Recurrent HSV Using High-Dimensional Flow Cytometry
… variants found in 2 HSV patients causing PLCγ2 hypophosphorylation, and loss of cytolytic function in NK cells is a novel finding recently published by Alinger et al from our lab in 2023. Prior to that study, <em>PLCG2</em> gain of function variants in B cells had been well studied but …
-
Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
… from Phospholipase-C-gamma 1 and 2 (PLCγ1and PLCγ2) knockout mice, we demonstrate that PLCγ2, but not PLCγ1, is required for activation of NF-κB and MAPK signaling pathways after <em>C. albicans </em>stimulation, resulting in impaired production of pro-inflammatory cytokines and reactive …
-
The role of BCAP in regulating the TLR signalling pathway
… interactome, in which PI3K p85α/p110δ and PLCγ2 were associated with the negative regulation of the TLR4 pro-inflammatory response. It is hypothesised that BCAP may facilitate the recruitment and activation of PI3K and PLCγ2 to the TLR signalosome. In this study, a robust protocol was …
-
The influence of oxidised low density lipoproteins on platelet activation
… kinase pathway involving the proteins Syk and PLCγ2, which were confirmed to be involved in MLCSer¹⁹ phosphorylation. Furthermore, oxLDL triggered a second pathway involving the activation of RhoA leading to the activation of Rho kinase and subsequent inhibition of MLCP. A receptor that has …
-
Regulation of Syk activity in GPVI-mediated platelet activation
… In TULA-2 deficient platelets, Syk and PLCγ2 were hyperphosphorylated compared to wild-type platelets. Deletion of TULA-2 resulted in enhanced GPVI-dependent platelet functional responses and a prothrombotic phenotype. c-Cbl has been shown to be a negative regulator of GPVI signaling, …
-
The Regulation of Phosphorylation Events in Platelets
… phosphorylation of downstream molecules Lat and PLCγ2 as well as platelet aggregation and secretion. Stimulation of surface receptors GPVI, CLEC-2, GPIb, and FcRIIa, all lead to the activation of tyrosine kinase pathways. The role for Syk in these pathways is essential and in the absence of its …
-
CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… not Gz. Phosphorylation of Syk (Y525/526) and PLCγ2 (Y759), were not affected by raft disruption in CLEC-2 agonist-stimulated platelets. Furthermore, tyrosine phosphorylation of the CLEC-2 hemi-ITAM was not effected when MβCD disrupts lipid rafts. Lipid rafts do not directly contribute to …
-
CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity
… phosphodiesterase gamma-2 (PLCγ2) and Akt), cytokine expression/stimulation and epigenetic programming. However, chronic in vitro stimulation of the BCR led to reduced Syk(Y352) phosphorylation upon re-stimulation after 24 h, 48 h and 72 h. Proliferation and differentiation …