Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"PLASMA STABILITY"”.
-
Plasma stability in a dipole magnetic field
The MHD and kinetic stability of an axially symmetric plasma, confined by a poloidal magnetic field with closed lines, is considered. In such a system the stabilizing effects of plasma compression and magnetic field compression counteract the unfavorable field line curvature and can stabilize …
-
A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… advantages over peptides, such as increased stability, enhanced bioavailability, and reduced immunogenicity, making IFRA3Q1 a promising therapeutic candidate. The primary objectives of this research are to validate IFRA3Q1’s efficacy in reducing RA symptoms in preclinical models and to …
-
Balancing Antitumor Efficacy and Safety Profile: α-Amanitin-Based Fc-Small Molecule Drug Conjugates for Targeted Prostate Cancer Therapy
… of the conjugates in healthy tissues and their plasma stability. Previous studies with ADCs proved that introducing silencing mutation in the Fc-backbone reduce Fcγ-mediated uptake in the liver. However, despite the reduced binding affinity of the Fc-backbone to FcγRI, tolerability did not …
-
A Structure-Activity Relationship Study with Isoquinolinone Compounds and Stromal Antigen 2 Mutant Ewing’s Sarcoma Cells and Synthesis of Small Molecules for Anticancer Activity Through TEAD Palmitoylation Inhibition
… increased the efficacy, general solubility, and plasma stability. Different delivery systems, such as liposomes, have been implemented to help identify the true active compound towards the cancer cell lines. The Hippo signaling pathway is a cell signaling pathway that was recently linked to …
-
Theoretical prediction of [tau]E and [beta]⁻ in a large aspect ratio LDX
… to study the confinement of a high-temperature plasma in the magnetic field of a superconducting ring of wire. The levitated magnet produces a poloidal closed-line magnetic field characteristic of an ideal point dipole or a hard core Z-pinch magnetic configuration. The point dipole and hard core …
-
NTS2-selective analogs as an alternative treatment to chronic pain
… as well as selectivity for NTS2. Next, plasma stability and affinity for NT receptors were assessed in vitro for each analog. Analogs with the most interesting pharmacological profile were tested for analgesic potential using different animal pain models such as model of acute thermal …
-
The Development of a Tumour-Responsive Format for Antibody Conjugates
… influence critical factors of the ADC such as stability, pharmacokinetics, and efficacy. Significant improvements have been demonstrated by use of alternative ‘non-IgG’ ADC formats, which has facilitated greater modulation of properties such as half-life and tumour penetration. Notwithstanding, …
-
Rotation generation and transport in tokamak plasmas
Plasma toroidal rotation is a factor important for plasma stability and transport, but it is still a fairly poorly understood area of physics. This thesis focuses on three aspects of rotation: momentum transport, Ohmic rotation reversals, and LHCD induced rotation. Momentum transport is approached …
-
Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents
… such as A.D.M.E, pharmacological factors such as stability within plasma and metabolic stability were measured. These are responsible for measuring the degradation of the compound over time and looking at the ability of the liver to remove the administered drug respectively. In addition, …
-
Fundamental study of magnetic field-assisted micro-EDM for non-magnetic materials
… problem, one aimed at altering the discharge plasma channel through the use of magnetic fields to affect plasma confinement and/or plasma stability and the other aimed to improve the material removal mechanism of the µ-EDM process through the use of Lorentz forces induced in the melt pool. …
-
The Development of Sulfatase-Cleavable Linkers for Antibody-Drug Conjugates
… suffer from a number of key drawbacks, such as instability in rodent blood and poor aqueous solubility. First, this thesis describes the design, synthesis and evaluation of arylsulfates as enzymecleavable ADC linkers. These arylsulfates were designed to be cleaved by lysosomal sulfatases, thus …
-
Stability and Control in Complex Networks of Dynamical Systems
Stability analysis of networked dynamical systems has been of interest in many disciplines such as biology and physics and chemistry with applications such as LASER cooling and plasma stability. These large networks are often modeled to have a completely random (Erdös-Rényi) or semi-random …
-
Pressure profiles of plasmas confined in the field of a dipole magnet
Understanding the maintenance and stability of plasma pressure confined by a strong magnetic field is a fundamental challenge in both laboratory and space plasma physics. Using magnetic and X-ray measurements on the Levitated Dipole Experiment (LDX), the equilibrium plasma pressure has been …
-
ΑΝΑΛΥΤΙΚΕΣ ΜΑΓΝΗΤΟΥΔΡΟΔΥΝΑΜΙΚΕΣ ΙΣΟΡΡΟΠΙΕΣ ΤΟΡΟΕΙΔΟΥΣ ΑΞΟΝΙΚΑ ΣΥΜΜΕΤΡΙΚΟΥ ΠΛΑΣΜΑΤΟΣ ΣΥΝΤΗΞΗΣ
… FREE CONFIGURATIONS RELEVANT TO THE SPHEROMAK PLASMA RELAXATION. MORE SPECIFICALLY. FIRST, IN ORDER TO DERIVE STATIC EQUILIBRIA OF ARBITRARY ASPECT RATIO AND DIFFERENT POLOIDAL CROSS SECTIONAL SHAPES, THE GRAD-SHAFRANOV EQUATION IS SOLVED IN SPHERICAL, PROLATE SPHEROIDAL, OBLATE SPHEROIDAL AND …