Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"PLA2"”.
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Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines
… studies from our laboratory showed that cPLA2α may be responsible for approximately 50-60% of the PGE2 production in response to inflammatory cytokines. Thus, we hypothesized that a closely-related PLA2 is responsible for 40-50% of the PGE2 produced in response to inflammatory cytokines. …
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Lipoprotein-associated phospholipase A2 (Lp-PLA2) Impact and role as cardiovascular risk marker
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is today considered a novel specific vascular inflammatory biomarker. The general aim of this thesis was to study the role and impact of Lp-PLA2 as cardiovascular (CV) risk marker in an epidemiologic perspective. Specific aims were to explore the …
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AVALIAÇÃO DA ATIVIDADE ANTILEISHMANIA DA PLA2 Lys49 MjTX-I, ISOLADA DA PEÇONHA DE Bothrops moojeni
… potential, among these, phospholipases A2 (PLA2) stand out. Thus, the objective of the present study was to evaluate the effect of PLA2 MjTX -I, isolated from Bothrops moojeni venom on the growth and viability of promastigote forms of Leishmania Leishmania amazonensis. In addition, were …
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L' effet polymorphisme d'un seul nucléotide (SNP) de la PLA2 de groupe IVC (cPLA2y) sur son activité enzymatique
… étudiée, la phospholipase de groupe IVC (cPLA2γ), fut découverte en 1998 par deux différents groupes de chercheurs soit Underwood et al., 1998 and Pickard et al., 1999. Toutefois, le papier de Pickard et al. démontra un polymorphisme d'un seul nucléotide (SNP) causant une mutation qui …
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A digestive phospholipase a2 in Midguts of worker honey bees, Apis mellifera : significance in lipid nutrition and health
Phospholipase A2 (PLA2) catalyzes hydrolysis of the fatty acid moiety from the sn-2 position of phospholipids. At least 16 groups of PLA2s are known in mammals. In insects, PLA2s occur in several tissues, where they act in a variety of biological functions, such as digestion, immune signaling, …
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Interaction of sPLA2 phospholipases with assemblies of natural and synthetic amphiphiles and the development of a drug delivery system for the treatment of breast cancer
… the substrate. One of them, phospholipase A2 (PLA2) cleaves the ester bond at the sn-2 position of the phospholipids. Secreted phospholipases A2 (sPLA2) are the cell-secreted PLA2s ubiquitously present throughout the body. The sPLA2s are smaller in size and structurally sturdier than their PLA2 …
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Phospholipase A 2 in der Parvovirus MVMp induzierten Zelllyse
… Es wurde vermutet, dass Phospholipase A2 (PLA2) Enzyme, die in sekretorische sPLA2, zytosolische cPLA2 und Ca2+-unabhängige iPLA2 unterteilt werden, aus den folgenden Gründen für diesen Zusammenhang von Bedeutung sein könnten. Zum einen sind sie als Phospholipidhydrolasen, neben der …
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The Relationship of Inflammatory Markers to Cognitive Function in a Population-Based Sample
… and Lipoprotein-associated phospholipase (Lp-PLA2) are pro-inflammatory blood markers that appear to play critical roles in atherosclerosis and vascular disease, and have been linked to Alzheimer’s Disease, vascular dementia, and subclinical levels of cognitive decline. The present study …
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The modulation of cytochrome P450 activities by their membrane lipid environment
… fractions with a range of phospholipase A2 (PLA2) concentrations at 37 °G on 4 CYP-catalysed reactions during microsomal fraction preparation was examined. The size of the membrane free fatty acid (FFA) pool was found to increase substantially following PLA2 treatment, and the main hydrolysis …
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A Missing link between lipid metabolism, inflammation and apoptosis: Phospholipase A2-activating protein (PLAA)
… and reduced the expression of annexin A4 (a PLA2 inhibitor) and clusterin. We demonstrated that extracellular clusterin limited the production of PGE2. We showed that upon TNF-¦Á stimulation, plaa high cells revealed enhanced PLA2 activation, COX-2 expression and PGE2 production. Furthermore, …
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Phospholipase A2 Induced Monocyte Chemotaxis to Apoptotic Cells
… the reaction catalyzed by the phospholipases A2 (PLA2) have been shown to induce monocyte chemotaxis either directly or indirectly. Some investigators have implicated a cytosolic calcium-independent PLA2 (iPLA2) in the production of these products during apoptosis. However, a recent report …
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Caracterização parcial e atividades biológicas do veneno da aranha brasileira Lasiodora sp (Aranae: Theraposidae)
… Foram identificadas duas proteínas: PLA2 e hialuronidase. ω-theraphotoxin-Asp3a, PLA2 e hialuronidase estão sendo descritas pela primeira vez compondo o veneno de Lasiodora sp. O veneno inibiu o crescimento e matou todos os microrganismos testados, com inibição mínima (MIC), mínima …
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Gut Health Benefits of Natural and Alkali-Processed Cocoa (Theobroma cacao) with and without Inulin
… and applied to a florescence assay measuring PLA2 inhibitory activity. The alkalized cocoa powder was found to have a significantly lower concentration of total polyphenols and total flavanols, as well as a lower mDP, suggesting that alkalization may affect larger procyanidins more than …
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Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury
… with hemorrhagic effects, and phospholipase A2 (PLA2), an enzyme upstream to cyclooxygenase-2 (COX-2) in the inflammatory cascade. We have found that preconditioning Crotalus venom increases endogenous fibrinogen, decreases perioperative hemorrhage, attenuates COX-2 activity, and reduces …
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Caracterización de las vías de la fosfolipasa A_2 en procesos de neurodegeneración inducidos por estrés oxidativo en la retina bovina
… las siguientes isoformas de la fosfolipasa A2 (PLA2): la isoforma citosólica (cPLA2), la isoforma independiente de calcio (iPLA2) y la isoforma secretoria (sPLA2), durante la toxicidad retiniana inducida por Fe2+. También analizamos las implicancias de las diferentes PLA2s en la regulación de la …
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Biomarcadores relevantes para diagnóstico precoce e prevenção de doenças cardiovasculares.
… discuss ion . CRP, homocysteine , Lp (a) Lp - PLA2 and MPO act in pathophysiological mechanisms stimulating the atherogenic and thrombogenic process. The measurement of D - dimer represents the formation and degradation of the fibrin clot in the dynamics of blood coag ulation. Levels of apoB …
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The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation
… membrane phospholipids by a phospholipase A2 (PLA2). The major phospholipase involved in this liberation of AA during the inflammatory response is group IVA cytosolic phospholipase A2 (cPLA2α). Previous studies from our laboratory demonstrated that the bioactive sphingolipid, …
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The identification and characterisation of antimicrobial peptides from snake and scorpion venom.
… along with four potential phospholipase A2 (PLA2) proteins have been identified (12-14 KDa). One of these peptides, isolated from black mamba venom (Dendroaspis polylepis) exerts moderate antimicrobial activity and has low cytotoxic properties making it an ideal candidate for future drug …
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Biomarkers of oxidative stress in models of schizophrenia.
… U937 cells, but not significantly. Cytoplasmic PLA2 activity in the three human cell lines was examined, and the basal level of cPLA2 activity was found to be comparable in the lymphoblastoid and IMR-32 cells, but significantly lower than that measured in the U937 cells. Supplementation of the …
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Biological response to 8-oxoguanine base released during DNA base excision repair
… stress, which arises from the Rac1-Ras-NOX-PLA2-LO pathways, does not have a significant role in the observed senescence.
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