Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PKMζ"”.
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SEX DIFFERENCES IN THE ROLE OF PKMζ IN DRUG SELF-ADMINISTRATION AND PREFRONTAL CORTEX SYNAPTIC PLASTICITY
… to determine the role of protein kinase M zeta (PKMζ), a protein involved in the trafficking of AMPA receptors (AMPARs), in drug taking behaviors and synaptic plasticity. PKMζ belongs to the protein kinase C family and is exclusively in the central nervous system. PKMζ is persistently active, …
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Sex differences in synaptic plasticity within the reward system: the role of PKMζ and implications for opioid use disorder
… in females. We then investigated the role of PKMζ, a glutamatergic AMPA receptor trafficking protein, in plasticity and opioid-taking. We found PKMζ plays a role in synaptic plasticity within the nucleus accumbens and it works to blunt oxycodone-taking and motivation in a dose-dependent …
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Withdrawal from Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities to Behavioral Deficits and Neurochemical Perpetuators of Neurotoxicity and Drug Seeking Behavior
… withdrawal from MA, and 3. sex differences in PKMζ</em> <em>and κOR signaling to assess female susceptibility to AMPAr trafficking dysfunction and drug seeking following withdrawal from MA. </em>These experiments were done to understand<em> </em>the<em> 4. neurochemical shifts underlying …