Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"PKM"”.
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Design and analysis of the three degrees of freedom parallel kinematic machine
The thesis is about design and analysis of a PKM with 3 DOF. The new PKM is designed as a machine tool in various applications in manufacturing. The PKM is optimized based on the developed stiffness model. Kinematics and dynamics of the new PKM is also modeled and simulated.
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Lokalisation des antiviralen Mx1 Proteins und seiner assoziierten Proteinkinase in nukleären Einschlusskörperchen
… die „Mx-interagierende Serin-/Threoninkinase“ PKM, da es sich um die einzige bislang bekannte Kinase in den PML NBs handelt. Durch verschiedene Experimente konnte die Wechselwirkungen zwischen PKM und Mx1 weiter charakterisiert werden und über gezielte Mutagenese gelang es, Domänen von PKM …
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Regulation of alternative splicing and its connections to cancer
… regulators of the alternative splicing of the PKM gene in cancer cells while the second part elucidates the molecular mechanism of how this mutually exclusive alternative splicing is regulated. The second piece investigates the molecular mechanism of how SRp38 functions as a splicing activator …
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Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
… regulation of the alternative splicing of the PKM gene in cancer cells, while the second part investigates the physical connections between the transcriptional apparatus and splicing factors. Cancer cells uniformly alter key aspects of their metabolism, including their glucose usage. In …
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Examining the roles of the pyruvate kinase isoforms, PKMI1 and PKM2, in systemic metabolism and tumor development
Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase, and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. PKM1 expression, on the other hand, is restricted mostly to skeletal muscle, heart, and brain. To …
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Design of 3-DOF parallel manipulators for micro-motion applications
… micro-motion parallel kinematic manipulators (PKM): a three degrees of freedom (3-DOF) micro-motion manipulator and a 3-DOF micro-motion manipulator with actuation redundancy. The 3-DOF micro-motion manipulator has three linear-motion driving units, and the 3-DOF micro-motion manipulator with …
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Development of Novel Piezo-Driven Parallel-Kinematics Micropositioning Stages
… stages based on parallel kinematic mechanisms (PKM) that are more suitable for micropositioning than their serial counterparts. In order to further improve their kinematic and dynamic performance, the stages are built as monolithic systems by using flexure hinges as their motion joints, …
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Modification of soybean proteins by immobilized proteases
… Immobilized trypsin and chymotrypsin had uniform pKm and were stable at high temperatures. The optimum pH for activity of immobilized enzymes could be changed by using different supports and different methods of immobilization. A multi-enzyme system with immobilized trypsin and chymotrypsin was …
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The Effects of Native Advertising Disclosure and Advertising Recognition on Perceptions of News Story and News Website Credibility: A Consumer Neuroscience Approach
… by the tenets of the Persuasion Knowledge Model [PKM] (Friestad & Wright, 1994) to uncover insights on whether disclosure serves as an effective measure in publishers' efforts of mitigating the potential of consumer deception. In particular, this study investigated the relationships between: (1) …
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Kinematic Calibration of Parallel Kinematic Machines on the Example of the Hexapod of Simple Design
The aim of using parallel kinematic motion systems as an alternative of conventional machine tools for precision machining has raised the demands made on the accuracy of identification of the geometric parameters that are necessary for the kinematic transformation of the motion variables. The …
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Biomarcadores de calidad en la carne de vacuno y porcino relacionados con situaciones de estrés
… glucógeno “GDBE”, PYGM, PGM1, Piruvato kinasa “PKM”, GAPDH, CKM, Triosa fosfato isomerasa “TPI”), proteínas de transporte (precursor de Serotransferrina “TF”) y autofagia (relación LC3-II/LC3-I). En global, en los distintos estudios realizados se ha podido demostrar que tanto factores …