Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"PKLR"”.
-
Characterization of Mechanisms That Mediate Cancer Metastatic Colonization
… Liver and red blood cell pyruvate kinase (PKLR) was identified as a driver of liver metastasis in experimental models. In patients, PKLR was found to be expressed at higher levels in liver metastases relative to primary colorectal cancer tumors and also overexpressed in the primary tumors …
-
Functional Investigation of Genetic Determinants of Red Blood Cell Traits
… (TF, TFR2) and nucleotide metabolism (GMPR, PKLR). To uncover the function of candidate genes in relation to red blood cell development, I established protocols to generate CRISPR/Cas9-based model systems in human erythroid cell lines (K562 and HUDEP-2) and induced pluripotent stem cells …