Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"PKG"”.
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Ischemic Preconditioning Protects Adult Rat Cardiomyocytes Against Necrosis but not Apoptosis, via Activation of PKG
… monophosphate (cGMP) dependent protein kinase (PKG) in necrotic and apoptotic pathways of many cell types is well established; however its role in the ischemic preconditioning (IPC) of cardiomyocytes is not clearly defined. In the current study, we assessed the hypothesis that PKG protects …
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Role of Protein Kinase G in Regulating Vascular Tone in Hypoxic Ovine Cerebral Arteries
… monophosphate (cGMP)-dependent protein kinase (PKG) has been shown to be the main mediator of NO-induced vasorelaxation. Less well understood is the behavior of this pathway in conditions of long term hypoxia (LTH). It was later shown that LTH attenuates the ability of PKG to mediate …
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Identification of the Apoptin tumour specific kinase/s
… Monophosphate dependent protein kinase (PKG) in the regulation of Apoptin has been investigated. PKC/PKG expression was investigated in cell lines in relation to Apoptin sensitivity. <br/>Subsequent modification of PKC/PKG kinase expression was investigated and its effects on Apoptin …
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
… PDE5, pPDE5, and cGMP-dependent protein kinase (PKG) were measured by Western blots and spectrophotometric assay. The results show that ischemia and I/R significantly increased expression of PDE5. H2O2 had no effect on PDE5 expression and activity but significantly increased PKG activity. We …
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Mammalian TIMELESS and Protein Kinase G: Partners Linking the Molecular Clockwork to Environmental Light
… determined that GLU activates Protein Kinase G (PKG), and that this activation is required for the mammalian GLU-induced phase advance. Since the Drosophila phase advance proceeds through phosphorylation-dependent degradation of Drosophila TIMELESS (dTIM), I hypothesized that the mammalian …
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Cellular signalling pathways involved in thermoprotection of neural ciruit function in the locust.
… (OA/cAMP/PKA) and nitrergic (NO/cGMP/PKG) signalling pathways and tested their involvement in conferring thermotolerance to the vCPG during heat stress. I found that long applications of octopamine, or increased adenylate cyclase activity generated vCPG thermotolerance and was …
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Rôle modulateur de l'oxyde nitrique dans la vasoconstriction et l'élévation du calcium intracellulaire induites par l'endothéline-1 et le thromboxane A[indice inférieur 2] dans des vaisseaux humains et de lapins
… et des inhibiteurs de la protéine kinase G (PKG). Nos résultats montrent que le 8-Br-cGMP atténue la tension induite par l'ET-1 en préventif et en curatif sans affecter le [Ca][indice inférieur i]. Par contre, les inhibiteurs de la PKG, le KT-5823 et le Rp-8-pCPT-cGMPS, atténuent la …
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Design, synthesis, and structure-activity relationship studies of dual Plasmodium falciparum phosphatidylinositol 4-kinase and cGMP-dependent protein kinase inhibitors
… (PI4K) and the cGMP-dependent protein kinase (PKG) inhibitors, based on two distinct chemotypes. Plasmodium PI4K and PKG are validated targets, each with the potential to deliver pan-stage active compounds with potentially moderate to low risk of resistance. Part 1 of this study focused on the …
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Effect of Long-term Hypoxia on Myometrial Contractility in the Pregnant Sheep
… expression, and cGMP-depended protein kinase (PKG) activity. Myometrium was collected from near-term pregnant sheep exposed to high altitude-associated LTH and from normoxic pregnant controls. After pretreatment with 10<sup>-8</sup> M oxytocin (OT), circular and longitudinal myometrial strips …
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Defining Molecular Mechanism of Egress in Cryptosporidium
… (SUB1), and cGMP-dependent protein kinase G (PKG) are essential for egress of Cryptosporidium parvum merozoites from host cells. Our results demonstrated that PKG and SUB1 are crucial mediators of merozoite egress, while CDPK5 did not seem to play a role. Cryptosporidiosis affects millions of …
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cGMP -Dependent Protein Kinase, Behavioral Plasticity, and Foraging in Honey Bees and Fruit Flies
… a gene encoding a cGMP-dependent protein kinase (PKG, foraging). I accomplish this by using a traditional genetic model---the fruit fly, Drosophila melanogaster , and a traditional behavioral model---the honey bee, Apis mellifera. Variation in the for gene results in naturally occurring behavioral …
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An investigation into the synaptic conditions and celluar mechanisms underlying cerebellar synaptic plasticity
… (NOS), guanylate cyclase (GC), protein kinase G (PKG) or the GABAB receptor antagonist CGP62349 was included into the perfusion medium. Application of a nitric oxide (NO) donor, a cyclic guanosine monophosphate (cGMP) analogue or a phosphodiesterase (PDE) type V inhibitor to prevent cGMP breakdown …
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PHOSPHODIESTERASE-5 INHIBITION: A NOVEL STRATEGY TO IMPROVE STEM CELL THERAPY IN THE HEART
… was abolished by inhibition of protein kinase G (PKG) using both a pharmacological inhibitor and selective knockdown with shRNAPKG1α suggesting a PKG-mediated mechanism. To show the effect of preconditioned ASCs in vivo, adult male CD-1 mice underwent myocardial infarction (MI) by occlusion of the …
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Topics In Statistical Inference For Treatment Effects
… paper presents a unified \proglang{R} software \pkg{ivmodel} for analyzing instrumental variables with one endogenous variable. The package implements a general class of estimators, $k$-class estimators, and two confidence intervals that are fully robust to weak instruments. The package also …
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Impaired tissue responsiveness to B-type natriuretic peptide in heart failure: biochemical bases.
… and partially restored by a protein kinase G (PKG) inhibitor KT5823. Furthermore, BNP inhibited the fMLP-induced phosphorylation of the NAD(P)H oxidase subunit p47phox at ser345. These findings led to the conclusion that BNP suppression of O₂⁻ generation is mediated by the cGMP-PKG signaling …
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The Role of Ca²⁺/CaM-Stimulated Phosphodiesterase 1C in Vascular Smooth Muscle cells of the Synthetic/Activated Phenotype
… while the expression of other markers, including PKG, vinculin, and beta-1 integrin were unaffected. Treatment with PDE1C siRNA also reduced cell migration, proliferation, and the ability of HASMCs to bind extracellular matrix proteins. These effects were mediated without any major changes in …
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Investigation of the SCN 2.2 Cell Line as a Model of the Central Mammalian Circadian Pacemaker
… by inhibition of cGMP-dependent protein kinase (PKG), a known element of several circadian regulatory pathways. As with the SCN, synchronized SCN 2.2 cultures expressed a gated response to glutamate stimulus in both induction of ser-133 phosphorylated cAMP response element binding protein (PCREB) …
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Regulation of blood platelet function by the AGC family of protein kinases
… the AGC family of Ser/Thr protein kinases (PKA, PKG and PKC). Once activated these kinase blunt platelet function through the phosphorylation of signalling proteins requested for activation. In this study, the role of AGC family kinases and their signaling cascades in regulating platelet function …
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Multidimensional profiling of the Toxoplasma gondii proteome
… kinase SPARK regulates the AGC kinases PKG, PKA C1, and PKA C3, which together control transitions within the asexual cycle of this important family of parasites.
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Investigation of the Signaling Mechanisms of the Pineal Hormone Melatonin in the in Vitro Rat Suprachiasmatic Nucleus
… study also showed that elements of the NO/cGMP/PKG signal cascade play no role in the melatonin phase shift, but that melatonin has interactions with several neuromodulators, such as NPY, PACAP, and cAMP. Furthermore, there are at least two different melatonin receptors identified in the rodent …
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