Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PKCalpha"”.
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Regulation of PKCalpha and the role of PKC in neuroblastoma cell migration
… atypical (zeta and iota/lambda) isoforms. When PKCalpha is inactive it is maintained in a closed conformation by intramolecular interactions. Upon activation these interactions are disrupted by binding proteins, membranes and activators. We have previously seen that stimulation with carbachol …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
… that DES decreased c-jun, Bcl-2, and PKCalpha mRNA expression. These results suggest a shift away from proliferative activity and may reflect alterations noted predominantly in the hematopoietic population. TCDD increased c-jun mRNA expression with modest decreases in PKCalpha, and …
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Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.
… formed when cells are exposed to stress. PKCalpha, rather than PKCε, was found to be the main PKC isoform found in these stress granules. We have furthermore discovered a role for PKCalpha in regulating stress granule formation.
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Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast Cancer
<p>The ErbB-2 gene is amplified and the resulting protein product overexpressed in 15-30% of breast tumors, and associated with aggressive behavior and poor overall survival. Currently, there are two FDA approved therapies targeting ErbB-2 for the treatment of ErbB-2 positive breast cancer: …