Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"PKC-zeta"”.
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… were performed using aspirin-treated platelets. PKC zeta is an atypical member of the PKC family of serine/threonine kinases. In this study, we have confirmed that it is expressed in human platelets and is constitutively phosphorylated at the activation loop threonine 410 as well as the turn …
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Role of protein kinase C isoforms in human breast tumor cell survival
Protein kinase C (PKC) is a family of serine/threonine kinases composed of 12 unique isoforms that function in a variety of cellular processes including proliferation, apoptosis, differentiation and carcinogenesis. The contribution of individual PKC isoforms to these processes is largely …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… IGF-I activates the PI 3-kinase-dependent PKC-$\zeta$ pathway during differentiation along the macrophage lineage. Inhibition of IGF-I-inducible PI 3-kinase leads to a complete block in PKC-$\zeta$ activation and abrogation of macrophage differentiation. Finally, it is demonstrated that the …
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Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
… in a manner that depends on protein kinase C (PKC)-mediated signaling. We identify PKC[epsilon] and PKC[zeta] as regulators of EC lumenogenesis in 3D collagen matrices. We further show that Src family kinases (SFKs) are involved in this PKC [epsilon]-mediated EC lumen formation process. SFKs …
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Unique localization of protein kinase C isozymes in T51B rat liver cells and their role in proliferation and apoptosis.
… of the G2 cell population. The role of PKC isozymes in the regulation of cellular homoestasis in T51B cells has also been studied. Immunofluorescence and immunoblot analyses demonstrate the presence of PKC-$\alpha,$ -$\beta\sb1,$ -$\delta,$ -$\epsilon$ and -$\zeta$ in the cytosol, the …
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Role of Protein Kinase C Zeta (PKCζ) in Regulation of Epithelial Tight Junctions
… In the present study we determined the role of PKCζ in occludin phosphorylation and the dynamics of tight junctions. Inhibition of PKCζ by specific PKCζ pseudo substrate rapidly reduced TER, increased inulin permeability and induced redistribution of occludin and ZO‑1 in Caco‑2 and MDCK cell …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… that a signaling pathway involving PI3K and PKC ζ is involved in SHP Thr phosphorylation, and also regulates arginine methylation of SHP. The close proximity of the phosphorylation (Thr-55) and methylation (Arg-57) sites suggested a possible interplay between them. Studies with …