Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"PKC-δ"”.
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The Role of PKC-δ in Hypoxia-induced Cerebrovascular Endothelial cell death.
In various cell types, PKC(protein kinase C)-δ has been found to be an important mediator during hypoxia-induced cell death. However, the role of PKC-δ in cerebrovascular endothelial cells is unknown. Therefore, we investigated the role of PKC-δ during hypoxia-induced cell death using bEnd.3 cell, …
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
… resistance (IR). Novel Protein kinase C (nPKC), is solely activated by diacylglycerol (DAG). Diacylglycerol has been found to be increased in the liver during NAFLD. Several studies have demonstrated a link between vitamin D deficiency, high fructose diet, and NAFLD in human and rodents. …
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Protein Kinase C - delta (PKC-δ): a critical hub for immunomodulatory functions in macrophages during Mycobacterium tuberculosis infection
… therapeutic intervention, Protein Kinase C – δ (PKCδ) has been recognized as a critical marker with clinical and experimental evidence in recent years. An experimental mouse model of global PKCδ knockout (PKCδ-/- ) revealed mechanistic alterations enhancing the susceptibility to various …
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… inhibitor genistein, the protein kinase C (PKC)-δ/ε inhibitor rottlerin, the general PKC inhibitor staurosporine, and the chloride channel inhibitors 4,4’-diisothiocyanatostilbene-2,2’-disulfonic acid (DIDS) and 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB). Protein expression of the …
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Tuberculosis transcriptomics: host protection and immune evasion mechanisms
… to Batf2, we showed that Protein Kinase C-delta (PKC-δ) deficient mice are highly susceptible to tuberculosis and human lung proteomics dataset revealed that PKC-δ was highly upregulated in the necrotic and cavitory regions of human granulomas in multi-drug resistant subjects. PKC-δ deficient mice …
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The effect of lifestyle modification on the insulin-signaling cascade among subjects with impaired glucose tolerance
… level of atypical forms of protein kinase C(PKC-ξ/λ) and active form of membrane-bound PKC-δ, -θ ,-α, and -β before and after insulin stimulation in both subjects groups. All the same assessment was repeated following 6 months of lifestyle modification(education of diet control and exercise) …
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The Effect of Weight Reduction on Chronic Inflammatory Molecules and Insulin Resistance in type 2 DM
… manner, atypical forms of protein kinase C(PKC-ξ/λ),which have also been suggested to mediate glucose transport. So we assessed the phosphorylation level of atypical PKC before and after insulin stimulation in both groups. Several studies have shown associations between increased PKC …
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U0126, MEK1/2 inhibitor, Induces Adhesion Molecules Expression in Human Blood Cells
… (antioxidant), rottlerin (an inhibitor for PKC-δ), and SN50 (an inhibitor for NF-kB) on U0126-induced adhesion molecule expression. Adhesion molecule expression was attenuated by rottlerin and trolox. In addition, to examine cell type specificity of U0126 effect on adhesion molecule, we …
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Mechanisms underlying Leishmania parasites survival and dissemination at late stage of infection in human macrophages
… apoptotic signaling pathways: AKT, NF-κB and PKC-δ. Further comparative proteomic analysis of this model supported these findings and showed that during L. aethiopica spreading, a number of host physiological processes were subverted. Specifically caspase-3 and caspase-9 activation strengthens …
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Chloride Channel 3 (CLC3), an Immune Antiporter in the Migration and Activation of Human Eosinophils in Allergic Asthma
… revealed that TGF-β regulates CLC3 through PKC-δ and SMAD3. Gene analysis disclosed multiple AP-1 binding sites on CLC3 gene, suggesting an important role of AP-1 in the regulation of CLC3. Using different bioinformatics tools, an uncharacterized CLC3 promoter was identified and cloned. …
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The novel role of epidermal growth factor (EGF) in the regulation of ion channels in the calu-3 submucosal cell line
… initial current at one hour via a EGFR-PI3K-PKC-δ-KCNN4/KCNQ1 signalling pathway. Similarly, preincubation with EGF also decreased forskolin induced short circuit current compared to untreated monolayers at 1 to 3 hours, with a recovery at 24 hours. The decreases were found to be dependent on …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… activation and Btg2 transcription. Furthermore, PKC activation was also found to be a critical factor mediating ROS-mediated signals to NF-κB pathway that culminate on Btg2 regulation, and specifically PKC-δ was responsible for this regulation under oxidative stress. Serum deprivation-associated …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… 2003). Nuclear translocation and activation of PKC-δ were reported to be necessary for saturated fatty acid-induced beta cell apoptosis (Eitel, 2003). Elevated concentrations of FFAs were found to produce reactive oxygen species (ROS) (Wang et al, 2004) and therefore, ROS and oxidative stress …