Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"PKC-β"”.
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Investigating the role of PKC-β in tumour activated stromal cells
… The Ringshausen lab have previously shown PKC-β to be a bone marrow stroma cell (BMSC) - autonomous signalling pathway critical for survival of malignant B-cells. PKC-β dependent cell contact factors have been shown to regulate drug resistance, but the role of soluble-factors for this …
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Profilo molecolare dei linfomi post-trapianto
… several new markers (Cyclin D2, Cyclin D3, p27, PKC-β, FOXP-1 and Survivin) identified as negative prognostic factors in DLBCL of the immunocompetent patient. Out of 50 DLBCL, 23 cases (46%) had an Activated B Cell (ABC) phenotype, 8 (16%) a Germinal Centre B-cell (GCB) phenotype, and 11 (22%) an …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… dehydrogenase (SORD) and protein kinase C- β(PKC-β). The A10 allele of the NFκB gene and H3 and H7 alleles of the HSP70-A2 gene were identified as risk markers of TIDM (P< 0.01). These alleles were not associated with microvascular complications. No evidence of associations was obtained …
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Synthesis and anticancer evaluation of novel, functionalised bisindolylmaleimides and indolocarbazoles
… and screening them against fungal and adipocyte PKC-β. These supplementary studies resulted in the identification of compounds as potent kinase inhibitors. A total of 6 BPC candidates progressed to five dose anticancer screening and demonstrated remarkable inhibition. A further 53 novel …
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The effect of lifestyle modification on the insulin-signaling cascade among subjects with impaired glucose tolerance
… level of atypical forms of protein kinase C(PKC-ξ/λ) and active form of membrane-bound PKC-δ, -θ ,-α, and -β before and after insulin stimulation in both subjects groups. All the same assessment was repeated following 6 months of lifestyle modification(education of diet control and exercise) …