Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"PKC-α"”.
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Effect of phosphorylcholine-based small molecule analogues of the immunomodulatory nematode product ES-62 on mast cell function
… complex with TLR-4 and subsequently sequestering PKC-α away from the high affinity receptor for IgE, FcεRI. In this work, PKC-α was found to be critical for mast cell degranulation and its degradation provided a mechanism for the ES-62-mediated disruption of key PLD-SPHK-dependent pathways of …
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Up-modulation of Hepatocyte Growth Factor/ c-Met Signaling by Protein Kinase C-g and its Mechanism
Protein kinase C (PKC) family is composed of 11 isoenzymes, and has been known to down-modulate the tyrosine kinase activity of c-Met, the receptor for hepaotcyte growth factor (HGF). However, specified roles by PKC isoenzymes on the regulation of HGF/c-Met signaling have never been addressed yet. …
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Quantitative Proteinexpressionsanalysen in den klinisch-pathologischen Subtypen Gastrointestinaler Stromatumoren (GIST)
… Proteinexpression von KIT PDGFRA, SCF, PKC-alpha, phospho-PKC-alpha, SRC, phospho-LYN, CRKL, AKT-1, phospho-AKT-1, ERK-2, FAK, PYK-2 und cyt-PP2A wurde in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und Mutationsstatus …
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The effect of lifestyle modification on the insulin-signaling cascade among subjects with impaired glucose tolerance
… level of atypical forms of protein kinase C(PKC-ξ/λ) and active form of membrane-bound PKC-δ, -θ ,-α, and -β before and after insulin stimulation in both subjects groups. All the same assessment was repeated following 6 months of lifestyle modification(education of diet control and exercise) …