Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"PKC isoforms"”.
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The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines.
… of cancer related deaths. Protein kinase C (PKC) isoforms have been shown to be strongly modulated in many androgen sensitive tumour cell lines. Increased expression of some PKC isoforms has also been linked to immortality in many cancer cell lines. Conjugated linoleic acids(CLAs) are …
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Role of protein kinase C isoforms in human breast tumor cell survival
Protein kinase C (PKC) is a family of serine/threonine kinases composed of 12 unique isoforms that function in a variety of cellular processes including proliferation, apoptosis, differentiation and carcinogenesis. The contribution of individual PKC isoforms to these processes is largely …
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Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Factor in Breast Cancer
Several protein kinase C (PKC) isoforms have been suggested as potential targets for breast cancer therapy. To explore the role for PKC isoforms in processes that facilitates malignant progression and the utility of PKC isoforms as biomarkers in breast cancer, we designed a study where we evaluated …
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Ruolo della PLCγ1 e della PKCε nel differenziamento miogenico
… pathways that required both PLCγ1 and PKCε, we investigated its role in insulin stimulation of skeletal muscle differentiation. The precise effects of insulin on specific PKC isoforms are as yet unknown. Insulin stimulation produced a gradual increase in PKCε expression and activation …
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Roles of protein kinase C in cell death and breast cancer
Aberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was …
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The Effects of Atypical Protein Kinase C on TGFβ Signalling
… thesis, I examined the role of Protein Kinase C (PKC) in the regulation of TGFβ signalling pathways and found that the Atypical PKC isoforms (aPKC; a subgroup of the PKC family) indeed can alter TGFβ receptor signaling. My work has shown that the modulation of aPKC expression or activity using …
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Signalling reactions of PI3Kgamma in T cells
… the PI3K class IA enzymes (alpha, beta and delta isoforms), but it was found that PI3Kgamma, the single member of class IB PI3K, is also involved in the regulation of activation-induced proliferation and cytokine production of T cells. How PI3Kgamma participates in this mechanism is largely …
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Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth
Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of …
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Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.
The protein kinase C (PKC) family of serine/threonine kinases consists of 10-15 members. The PKC isoforms have central roles in many essential cellular processes, including proliferation, apoptosis, differentiation, cytoskeletal changes, and migration. The PKC family can be subgrouped into …
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Molecular mechanisms underlying Juvenile hormone (JH) signaling pathway
… aims to determine the role of protein kinase C (PKC) in JH signaling in adult mosquitoes and to find the direct target genes of Krüppel homolog 1 (Kr-h1), a zinc finger transcription factor encoded by a JH early response gene. We discovered that PKC is an essential component of a …
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Role of mural Cx43 in vascular interactions and its regulation by breast tumor cells
… cells to tumor conditioned media (CM) activates PKC signaling in mural cells, resulting in inactivating phosphorylation of Cx43 at the PKC site S368 that is both rapid and sustained. Although tumor CM activates several of the PKC isoforms expressed by vSMC, using a panel of pharmacological …
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Regulation of glucagon secretion from pancreatic alpha cells
… as PKA. In addition to PKA, protein kinase C (PKC) was also found to be involved in the regulation of glucagon secretion from both human and murine α-cells. Inhibition of PKC using a pharmacological antagonist suggested that tonic background activity of PKC is required to maintain a high …
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CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
… the expression of different Protein kinase C (PKC) isoforms in eosinophils induced to undergo apoptosis by serum withdrawal, and investigated the role of PKC-8 in regulating eosinophil survival and apoptosis. PKC expression was measured under survival and apoptotic conditions, as well as in …
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Molecular Mechanisms of Presynaptic Plasticity and Function in the Mammalian Brain
… by calcium-dependent protein kinase C (PKC) isoforms that phosphorylate Munc18-1 proteins. It is unknown how generally applicable this mechanism is throughout the brain and if other proteins might be able to modulate PTP. Combining genetic (PKCαβy triple knockout [TKO] and Munc18-1SA …
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Characterization of the Beta-2 Adrenergic Receptor Mechanism in Bovine Neutrophils, and Some Effects of Inflammatory Stimuli on its Function
… this phenomenon by activating protein kinase C (PKC) via phorbol 12-myristate 13-acetate (PMA) administration. However, preincubation with PMA actually increased terbutaline-mediated cAMP production, in a dose and time-dependent manner. At this time, we cannot explain why increasing the dose of …
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Phosphorylation sites on specific neuronal proteins can control the mode of synaptic vesicle exocytosis and thereby regulate synaptic transmission
… at the active zone produced by HK5C activates PKC isoforms, which in turn cause phosphorylation of myosin-II and dynamins. It is hypothesised that dynamins are active at relatively lower increases in [Ca2+]i that do not activate PKCs whereas myosin-II is active at relatively higher increases in …