Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"PKC delta"”.
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Repression of Protein Kinase C Delta in Human Squamous Cell Carcinomas by Ras, Fyn and NF-Kappa B Signaling
<p>The delta isoform of Protein Kinase C (PKC-delta) is widely expressed in many normal tissues, including epidermal keratinocytes, and has a critical role in UV-induced apoptosis. However, PKC-delta is frequently lost in chemically or UV-induced mouse skin tumors, as well as in human cutaneous …
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Role of protein kinase C isoforms in human breast tumor cell survival
Protein kinase C (PKC) is a family of serine/threonine kinases composed of 12 unique isoforms that function in a variety of cellular processes including proliferation, apoptosis, differentiation and carcinogenesis. The contribution of individual PKC isoforms to these processes is largely …
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The analysis of B cell antigen receptor (BCR) mutants deficient in antigen-independent signaling reveals novel BCR-associated proteins
… 5’-phosphatase (SHIP) and the protein kinase C delta. <br>Tyrosine phosphorylation of SHIP in response to PV stimulation was critically dependent on <br>the integrity of the Ig-alpha C-terminus. SHIP could be phosphorylated by both BCR-proximal <br>protein tyrosine kinases, Lyn and Syk. The …
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The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines.
… of cancer related deaths. Protein kinase C (PKC) isoforms have been shown to be strongly modulated in many androgen sensitive tumour cell lines. Increased expression of some PKC isoforms has also been linked to immortality in many cancer cell lines. Conjugated linoleic acids(CLAs) are …
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The Role of a Membrane Androgen Receptron in the Brain
… and increased TUNEL staining. In addition, PKC-delta mediated DHT-BSA-induced cell death, since antagonism of PKC-delta with rottlerin afforded protection. In conclusion, we have partially characterized a novel mAR in astrocytes during injury. Here, the damaging effects of androgens, at …
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Caractérisation du rôle du récepteur P2X7 dans le transport du glucose par les cellules épithéliales intestinales et le contrôle de la glycémie et du métabolisme
… impliquant les protéines PI4K, PLC[gamma]-1, PKC[delta] et PKD1. Nous avons alors entrepris une série d’études pour déterminer quel était l’impact d’une délétion du gène P2rx7 sur le métabolisme du glucose dans un modèle de souris pour lequel l’expression de P2rx7 est invalidée (P2rx7-/-). …
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Design, Development, Characterization and Testing of CD22 Targeted Long Circulating Liposomal Drug Delivery Systems for B Cell Malignancies
… and cardiomyopathy. AD 198 is a novel PKC-delta activating agent that has cytotoxic superiority over doxorubicin by being able to circumvent resistance mechanisms developed by the cancer cells towards doxorubicin and being cadioprotective from the damage caused to cardiomyocytes by …
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Unique localization of protein kinase C isozymes in T51B rat liver cells and their role in proliferation and apoptosis.
… of the G2 cell population. The role of PKC isozymes in the regulation of cellular homoestasis in T51B cells has also been studied. Immunofluorescence and immunoblot analyses demonstrate the presence of PKC-$\alpha,$ -$\beta\sb1,$ -$\delta,$ -$\epsilon$ and -$\zeta$ in the cytosol, the …
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A mechanism for SCA10 neurodegeneration due to intronic repeat expansion
… in the translocation of Protein Kinase C ä (PKCä) to mitochondria, where it is known to activate apoptosis. Both induction of this mechanism through endogenous expression of expanded repeat and inactivation of hnRNP K, as well as rescue of the mechanism via reduced levels of Ataxin 10 …
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
… canine A2AAR is phosphorylated in response to PKC activation. Interestingly, several proteins have recently been identified as being able to interact with the C-terminal tail of the A2AAR. However, how these interactions are regulated is not known. One of the aims of this study was to …
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The Tumor Suppressor PKCδ Is Critical for UV-Induced G2/M Checkpoint Activation and Apoptosis
<p>Protein kinase C delta (PKCδ) is an essential component of the intrinsic apoptotic program. Following DNA damage, such as exposure to UV radiation, PKCδ is cleaved in a caspase-dependent manner, generating a constitutively active catalytic fragment (PKCδ-cat) which is necessary and sufficient …