Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"PKCα"”.
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Regulatory Factors of Cellular Senescence in Human Diploid Fibroblast : SA-p-Erk1/2, PP1/2A, PKCα
Proliferation of normal diploid cells is arrested irreversibly after a certain number of divisions, called replicative senescence, which is paragon of the general process of cellular senescence. Once senescent, cells continue to function metabolically, but will not respond to mitogens. Decreased …
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Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Factor in Breast Cancer
… a study where we evaluated the expression of PKCα, δ, and ε in primary breast cancers as well as in breast cancer cell lines. We found that PKCα levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKCδ and PKCε did not correlate …
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… carcinogenesis in CD-1 mice. Upon TPA treatment, PKCα and PKCβ1 played differentially in the nuclear translocation of senescence-associated pErk1/2, which regulates reversal of senescence; PKCα carried pErk1/2 to nuclei after freed from PEA-15pS104 by PKCβ1, and then rapidly degraded by …
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Regulation of cellular growth and identification of stromal gene signatures in breast cancer
… lines, we have found that the protein kinase Cα (PKCα) isoform can influence stress granule formation in a stress inducer-specific way. Depletion of PKCα led to a delayed stress response along with an initial loss of eIF2α phosphorylation in heat shock, but not arsenite, treated cells. G3BP …
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Microgravity Exerts an Age-Dependent Effect on Cardiovascular Progenitor Cell Development
… to activation of protein kinase C alpha (PKCα), a calciumdependent protein kinase, and Akt, a regulator of stem cell self-renewal, after 30 days. To explore the effect of calcium induction in neonatal CPCs, we activated PKCα using hWnt5a treatment on Earth, which resulted in an induction …
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Molecular Characterization of Dopamine Transporter Phosphorylation and Regulation
… that a variety of protein kinases including PKCα, PKA, CaMKII, and MAPKs phosphorylate a recombinantly expressed N-terminal tail of DAT (NDAT) <em>in vitro</em>. Phosphoaminoacid analysis specifically showed that PKCα phosphorylates on serine(s) and ERK1 phosphorylates on threonine(s) of …
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Roles of protein kinase C in cell death and breast cancer
… gene expression analysis. We found that high PKCα levels correlate with poor prognosis, high proliferation and estrogen receptor negativity. We have also seen that PKCα suppresses the expression of stanniocalcin-1 in breast cancer cells. Previous reports have shown that PKCδ is a survival …
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Function and Regulation of Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex1) in Cancer
… expression. MCF-7 cells express PMA-sensitive PKCα, δ, ε, and η. The PKC general inhibitor Gö6983, but not the PKCα-selective inhibitor Gö6976, blocked the PMA down-regulation of P-Rex1 expression and breast cancer cell proliferation. Overexpression of a constitutively active PKCε mutant …
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Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
… known kinase inhibitor, preferentially targeting PKCα. We developed a high throughput approach by which we identified this compound able to reduce YAP-induced proliferation and clonogenicity of PDAC cellsin vitro, despite it leads to increased YAP nuclear levels. The Hippo pathway is the main …
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Cellular signalling pathways involved in muscle atrophy in cancer cachexia
… C2C12 myoblasts transfected with mutant IkBα and PKCα inserts did not elicit a PIF-induced response, suggesting the importance of the transcription factor NF-kB and PKC involvement in PIF signal transduction. 15(S)-HETE acts as an intracellular mediator of PIF and exerts an effect through the …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… PIEZO1 induced calcium-dependent activation of PKCα-ERK and Pyk2-p38 axes, promoted chemokine expression and myofibroblast transition. Pharmacological inhibition of Pyk2 recapitulated the effects of genetic ablation, suppressing hypertrophy, fibrosis, and partially cardiac dysfunction in vivo. …
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Las diacilglicerol quinasas en los núcleos de las células fotorreceptoras de la retina bovina : efectos de la luz y la insulina
… el PIP2. También demostramos la presencia de la PKCα en la FNF, PKC de tipo convencional que es activada en presencia de Ca2+ y DAG. La exposición de las retinas a la luz produjo un aumento del estado de fosforilación de la PKCα. Dado que la fosforilación de PKC puede ser mediada por la …