Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 249 for “"PKC"”.
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Cardiolipin Regulates Mitophagy Through The Pkc Pathway
… compensate for decreased mitophagy.</p> <p>The PKC and HOG MAPK pathways are known to be required for mitophagy. crd1Δ growth defects are exacerbated by deletion of HOG pathway genes SHO1, SSK1, STE50 and HOG1, and rescued by stimulating the HOG pathway and upregulating the PKC pathway. These …
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
… were performed using aspirin-treated platelets. PKC zeta is an atypical member of the PKC family of serine/threonine kinases. In this study, we have confirmed that it is expressed in human platelets and is constitutively phosphorylated at the activation loop threonine 410 as well as the turn …
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Role of ROK and PKC in Permeabilized Rabbit Femoral Artery
… For a comparison we also used various PKC and MLCK inhibitors and repeated these experiments in intact tissues. We found that either [Ca2+]i alone does not directly activate ROK or the permeabilization technique itself disrupts the normal ROK signaling system. Secondary findings …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… have shown an involvement of protein kinase C (PKC) and extracellular signal-regulated kinases (ERK) 1/2 in ischemia. The aim of this thesis was to further elucidate the mechanisms underlying this receptor upregulation process, both in experimental ischemia and in organ culture of rat MCA. The …
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Characterizing PDK4 and PKC-Theta in Pancreatic Cancer and Cachexia
… skeletal muscles. Protein Kinase C theta (PKCθ) is a lipid-sensitive kinase expressed in skeletal muscle where it regulates insulin signaling. It is also expressed in T cells, and its deletion alleviates inflammation in several inflammatory conditions. We found that PKCθ expression …
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Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat
… in the gene coding for protein kinase C-gamma (PKC-γ). Experiment 1 was carried out to examine levels of two groups of molecules in the midbrain cell groups using quantitative immunofluorescence microscopy of cell bodies or their surrounding neuropil (a) those molecules giving information about …
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Investigating the role of PKC-β in tumour activated stromal cells
… The Ringshausen lab have previously shown PKC-β to be a bone marrow stroma cell (BMSC) - autonomous signalling pathway critical for survival of malignant B-cells. PKC-β dependent cell contact factors have been shown to regulate drug resistance, but the role of soluble-factors for this …
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The Role of Cyclin E In Pkc Iota-Driven Early Ovarian Tumorigenesis
… that are overexpressed in ovarian cancer, PI3K, PKCiota, and cyclin E, all of which have been shown to lead to a poor prognosis and decreased survival, converge into a single pathway that could potentially be targeted therapeutically.</p> <p>Because of the ability of either PKCiota or cyclin E …
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Regulation of PKCalpha and the role of PKC in neuroblastoma cell migration
Members of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in cellular regulation. Depending on differences in regulation, PKCs can be divided into classical (alpha, betaI, betaII and gamma), novel (delta, epsilon, eta and theta) and atypical (zeta and iota/lambda) …
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The Role of PKC-δ in Hypoxia-induced Cerebrovascular Endothelial cell death.
In various cell types, PKC(protein kinase C)-δ has been found to be an important mediator during hypoxia-induced cell death. However, the role of PKC-δ in cerebrovascular endothelial cells is unknown. Therefore, we investigated the role of PKC-δ during hypoxia-induced cell death using bEnd.3 cell, …
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Domains of the NR2A and NR2B subunits involved in NMDA receptor current modulation by PKC.
… involved in NMDA receptor current modulation by PKC.
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
… resistance (IR). Novel Protein kinase C (nPKC), is solely activated by diacylglycerol (DAG). Diacylglycerol has been found to be increased in the liver during NAFLD. Several studies have demonstrated a link between vitamin D deficiency, high fructose diet, and NAFLD in human and rodents. …
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The Role Of Pkc Epsilon In Breast Cancer Cell Surface Polyfibronectin Assembly And Pulmonary Metastasis
… to assemble polyFn was impaired by disruption of PKC-epsilon function. Knockdown of fibronectin also abolished polyFn formation. Cells with knockdown of either PKC-epsilon or fibronectin both had diminished ability to colonize the lungs in rat tail vein injection metastasis model. To further …
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The Role of Atypical PKC in the Plasticity of the Circadian Clock in the Rat Suprachiasmatic Nucleus
… examined the role of atypical protein kinase C (aPKC) in GLU signaling. We found that the phosphotransferase activity of aPKC is increased significantly by GLU treatment to SCN brain slices at CT 14 in the early night. Disruption of aPKC phosphotransferase activity completely blocks GLU-induced …
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The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines.
… of cancer related deaths. Protein kinase C (PKC) isoforms have been shown to be strongly modulated in many androgen sensitive tumour cell lines. Increased expression of some PKC isoforms has also been linked to immortality in many cancer cell lines. Conjugated linoleic acids(CLAs) are …
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Protein Kinase C - delta (PKC-δ): a critical hub for immunomodulatory functions in macrophages during Mycobacterium tuberculosis infection
… therapeutic intervention, Protein Kinase C – δ (PKCδ) has been recognized as a critical marker with clinical and experimental evidence in recent years. An experimental mouse model of global PKCδ knockout (PKCδ-/- ) revealed mechanistic alterations enhancing the susceptibility to various …
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Signal transduction events in human NK cells: role of PKC and calcium uptake in activated and inactivated NK cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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