Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"PKA signaling"”.
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… the possible link between them and the signaling pathways activated during hypertrophy. Here we show, for the first time, that angiotensin-(1-9) prevents intracellular calcium dysregulation and the activation of Calcineurin/NFAT signaling pathway at a transcription and protein level in a …
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The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior
… may regulate dopamine-cAMP dependent kinase (PKA) signaling, we identified, confirmed, and characterized Cdk5-dependent phosphorylation of Thr69 RIIβ. We generated novel phosphorylation state-specific antisera to pThr69 RII-beta and found that pThr69 RII-beta levels were reduced in conditional …
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The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… activation stimulates cAMP production and PKA signaling. Protein Kinase A (PKA) signaling then triggers EGF receptor activation, which activates the Mitogen Activated Protein Kinase (MAPK) cascade to promote steroidogenic acute regulatory (StAR) phosphorylation and translocation to the …
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Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP.
… of pyruvate cycling. We have also showed that PKA signaling is stimulated by glucose, and that inhibition of PKA decreases glucose-stimulated insulin secretion in INS-1 832/13 cells.
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Mutational analysis of Hsp110 suggests an integral role for the chaperone in yeast prion propagation.
… at 37oC. Disruption to cell wall integrity signaling was explored as a possible reason for this phenotype but evidence from this study suggests that G616D may disrupt PKA signaling. Comparative analysis of Sse1 and Sse2 reveals that Sse1 is more thermostable than Sse2 and Sse1 propagates …
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
… adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway. In the mammalian heart, increasing cAMP-PKA activity leads to phosphorylation of an array of proteins involved in increasing heart contractility and rate. β2AR also has a cardiac protective role through utilizing multiple …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
Up-regulation of cAMP/PKA signaling by drugs of abuse may contribute to escalation and relapse, possibly by differentially altering dopamine receptor-responsiveness in the mesolimbic dopamine system. To investigate this hypothesis, our initial studies measured alterations in cAMP-dependent and …
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The Non-genomic Signaling Pathways Mediated By G-protein Coupled Estrogen Receptor 1 (GPER) In Coronary Arteries
… directly activated by cAMP (Epac) as well as PKA; and 4) activation of GPER potentiates coronary artery contraction by a G??/EGFR-dependent pathway. Isometric tension studies were performed on endothelium-denuded porcine coronary arteries to test the function role of GPER and its signaling …
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Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… by the commensal flora and may mediate signaling to differentiated epithelia of the small intestine and colon. Yet, SPRR2 function in the GI tract is largely unexplored. Using the Caco-2 model of intestinal epithelial differentiation along the crypt-villus axis, we hypothesized that …
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Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets
… beyond the triggering of cyclic nucleotides signaling pathways. The aim of this study was to improve our understanding of platelet regulation by cAMP signaling networks.We observed differences in cAMP signaling depending on the agonists used. Using phosphorylation of PKA substrates as a …
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… thesis was to investigate the regulation of LKB1 signaling pathways in adipocytes, with a focus on SIK2, which is of particulate interest in adipocytes due to its high abundance in these cells. We show that AMPK activity is regulated by LKB1 and CaMKK in adipocytes and describe a regulation of …
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Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
… mapped to the gene, RIC8, a regulator of cAMP-PKA signaling. RIC8 variation is predicted to contribute to differences in thermal tolerance, melanin production, and capsule size. </p><p> </p><p>In combination, the studies reported here advance our understanding of the mechanisms that generate …
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Mechanism of genistein in the regulation of pancreatic beta-cell proliferation
… that genistein activates cAMP/protein kinase A (PKA) signaling in both clonal β-cells and mouse islets. Here I present evidence that genistein induced cellular proliferation of clonal rat pancreatic β-cells (INS1) and human islets following 24 h of incubation. This effect was dose-dependent …
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The anti-diabetic mechanisms by isoflavone genistein
… insulin secretion and proliferation and cellular signaling related to these effects in vitro and in vivo. We then determined its anti-diabetic potential in insulin-deficient and obese diabetic mouse models. The results in our study showed that exposure of clonal insulin secreting (INS1E) cells or …