Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"PK11195"”.
-
Tau pathology, microglia activation, and network dysfunction in Alzheimer’s disease
… tracer (measuring in vivo tau pathology) or [11C]PK11195 ligand (indexing in vivo neuroinflammation), with 2) connectivity measures of resting-state functional magnetic resonance imaging. I found increased [18F-AV]-1451 binding (reflecting tau pathology) in AD patients, relative to controls, in …
-
The role of tau and neuroinflammation in Progressive Supranuclear Palsy and Alzheimer's Disease
… of the PET radiotracers [18F]AV1451 and [11C](R)-PK11195 to compare the distribution and intensity of tau pathology and neuroinflammation respectively, in PSP and AD. I use both in vivo scanning and post mortem tissue from archival cases in the Cambridge Brain Bank. For the in vivo studies, I …
-
In vivo pathology markers in tauopathies: prognostic and diagnostic implications
… dementia and PSP. I use the PET ligand [11C]PK11195 PET as a marker of microglial activation, and [18F]AV-1451 PET to quantify tau pathology (or in the case of frontotemporal dementia, tau and/or TDP-43 pathology), with structural 3T MRI as an index of atrophy. In patients with Alzheimer’s …
-
Investigating immunosuppression as a disease modifying strategy in Parkinson's disease
… of AZA-PD trial participants who had [11C]- PK11195 PET prior to starting treatment, which assesses microglia activation. The [11C]- PK11195 binding potential in regions of interest is compared to that of a previously collected control cohort. This analysis suggests the pallidum, putamen and …
-
Fatigue in Cerebral Small Vessel Disease and its Relationship to Cognitive Behavioural Symptoms
… system (CNS) as assessed by <sup>11</sup>C-PK11195 PET and peripheral as assessed by circulating blood biomarkers) were investigated as possible mechanisms associated with fatigue, before moving on to assess the role of cognitive behavioural symptoms in the prevalence and severity of …
-
Lewy Body Dementia and the Role of Inflammation
… gender matched healthy controls underwent [11C]PK11195 PET imaging, and the same cohorts, plus an additional 10 matched control subjects underwent peripheral cytokine analysis. Results: The clinical prevalence rate of LBD was low compared to the known pathology rates, with delays identified in …
-
The neuroinflammatory basis of disease progression and cognitive impairment in Parkinson's disease
… This study involved PET neuroimaging with [11C]PK11195, a marker of neuroinflammation, and [18F]AV-1451, a radioligand used to visualize tau accumulation, as well as immunophenotyping and TLR expression analysis in the blood and cerebrospinal fluid. PET imaging with [11C]PK11195 showed an …
-
The role of cerebral small vessel disease in dementia
… PET imaging of [11C]PiB, [18F]AV-1451, and [11C]PK11195, respectively. For insights into the pre-clinical stages of AD pathogenesis, we examined cognitively healthy midlife adults from the PREVENT-Dementia study. We investigated whether well-established risk factors of late-life dementia were …
-
Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… whereas the binding potential of 11C-PK11195 radioligand administered during PET scans quantified microglial signal (neuroinflammation). For the PET-MRI-SVD study, the outcome variables were longitudinal progression to VCI, cognitive subdomain scores, and hippocampal and whole-brain …
-
Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementia
Frontotemporal dementia (FTD) is clinically and pathologically diverse, encompassing the behavioural variant FTD; non-fluent variant primary progressive aphasia; and semantic variant primary progressive aphasia. These are usually associated with either tau or TDP-43 pathology, with highly variable …